Cigarette smoking and risk of ovarian cancer: a pooled analysis of 21 case-control studies

被引：80

作者：

Faber, Mette T. ^{[1
]}

Kjaer, Susanne K. ^{[1
,2
]}

Dehlendorff, Christian ^{[3
]}

Chang-Claude, Jenny ^{[4
]}

Andersen, Klaus K. ^{[3
]}

Hogdall, Estrid ^{[1
,5
]}

Webb, Penelope M. ^{[6
]}

Jordan, Susan J. ^{[6
]}

Rossing, Mary Anne ^{[8
,9
]}

Doherty, Jennifer A. ^{[8
,10
]}

Lurie, Galina ^{[11
]}

Thompson, Pamela J. ^{[11
]}

Carney, Michael E. ^{[11
]}

Goodman, Marc T. ^{[11
]}

Ness, Roberta B. ^{[12
]}

Modugno, Francesmary ^{[13
,14
]}

Edwards, Robert P. ^{[15
,16
]}

Bunker, Clareann H. ^{[17
]}

Goode, Ellen L. ^{[18
]}

Fridley, Brooke L. ^{[19
]}

Vierkant, Robert A. ^{[19
]}

Larson, Melissa C. ^{[19
]}

Schildkraut, Joellen ^{[20
,21
]}

Cramer, Daniel W. ^{[22
]}

Terry, Kathryn L. ^{[23
]}

Vitonis, Allison F. ^{[22
]}

Bandera, Elisa V. ^{[23
]}

Olson, Sara H. ^{[24
]}

King, Melony ^{[25
]}

Chandran, Urmila ^{[23
]}

Kiemeney, Lambertus A. ^{[26
,27
,28
]}

Massuger, Leon F. A. G. ^{[29
]}

van Altena, Anne M. ^{[29
]}

Vermeulen, Sita H. ^{[26
]}

Brinton, Louise ^{[30
]}

Wentzensen, Nicolas ^{[30
]}

Lissowska, Jolanta ^{[31
]}

Yang, Hannah P. ^{[30
]}

Moysich, Kirsten B. ^{[32
]}

Odunsi, Kunle ^{[33
]}

Kasza, Karin ^{[32
]}

Odunsi-Akanji, Oluwatosin ^{[32
]}

Song, Honglin ^{[34
]}

Pharaoh, Paul ^{[34
]}

Shah, Mitul ^{[34
]}

Whittemore, Alice S. ^{[35
]}

McGuire, Valerie ^{[35
]}

Sieh, Weiva ^{[35
]}

Sutphen, Rebecca ^{[36
]}

Menon, Usha ^{[37
]}

机构：

[1] Danish Canc Soc, Unit Virus Lifestyle & Genes, Res Ctr, Strandblvd 49, DK-2100 Copenhagen, Denmark

[2] Copenhagen Univ Hosp, Gynecol Clin, Copenhagen, Denmark

[3] Danish Canc Soc, Unit Stat Bioinformat & Registry, Res Ctr, DK-2100 Copenhagen, Denmark

[4] German Canc Res Ctr, Div Canc Epidemiol, Heidelberg, Germany

[5] Univ Copenhagen, Herlev Univ Hosp, Dept Pathol, Mol Unit, Copenhagen, Denmark

[6] Queensland Inst Med Res, Populat Hlth Dept, Brisbane, Qld 4006, Australia

[7] Peter MacCallum Canc Ctr, East Melbourne, Vic, Australia

[8] Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, Program Epidemiol, Seattle, WA 98104 USA

[9] Univ Washington, Dept Epidemiol, Seattle, WA 98195 USA

[10] Geisel Sch Med Dartmouth, Epidemiol & Biostat Sect, Dept Community & Family Med, Lebanon, NH USA

[11] Univ Hawaii, Ctr Canc, Program Epidemiol, Honolulu, HI 96822 USA

[12] Univ Texas Houston, Sch Publ Hlth, Houston, TX USA

[13] Univ Pittsburgh, Sch Med, Div Gyn Onc, Dept Ob Gyn RS, Pittsburgh, PA USA

[14] Univ Pittsburgh, Grad Sch Publ Hlth, Dept Epidemiol,Magee Womens Res Inst,Canc Inst, Ovarian Canc Ctr Excellence,Womens Canc Program, Pittsburgh, PA USA

[15] Univ Pittsburgh, Div Gyn Onc, Dept Ob Gyn RS, Pittsburgh, PA USA

[16] Univ Pittsburgh, Ovarian Canc Ctr Excellence, Pittsburgh, PA USA

[17] Univ Pittsburgh, Grad Sch Publ Hlth, Dept Epidemiol, Pittsburgh, PA USA

[18] Mayo Clin, Coll Med, Div Epidemiol, Dept Hlth Sci Res, Rochester, MN USA

[19] Mayo Clin, Div Biomed Stat & Informat, Dept Hlth Sci Res, Rochester, MN USA

[20] Duke Univ, Med Ctr, Dept Community & Family Med, Durham, NC 27710 USA

[21] Duke Canc Inst, Canc Prevent Detect & Control Res Program, Durham, NC USA

[22] Brigham & Womens Hosp, Obstet & Gynecol Epidemiol Ctr, Boston, MA 02115 USA

[23] Univ Med & Dent New Jersey, Robert Wood Johnson Med Sch, Canc Inst New Jersey, New Brunswick, NJ USA

[24] Mem Sloan Kettering Canc Ctr, Dept Epidemiol & Biostat, New York, NY 10021 USA

[25] UMDNJ Sch Publ Hlth, Piscataway, NJ USA

[26] Radboud Univ Nijmegen, Med Ctr, Dept Epidemiol Biostat & HTA, NL-6525 ED Nijmegen, Netherlands

[27] Radboud Univ Nijmegen, Med Ctr, Dept Urol, NL-6525 ED Nijmegen, Netherlands

[28] Radboud Univ Nijmegen, Med Ctr, Ctr Comprehens Canc, NL-6525 ED Nijmegen, Netherlands

[29] Radboud Univ Nijmegen, Med Ctr, Dept Gynecol, NL-6525 ED Nijmegen, Netherlands

[30] NCI, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA

[31] M Sklodowska Curie Mem Canc Ctr & Inst Oncol, Dept Canc Epidemiol & Prevent, Warsaw, Poland

[32] Roswell Pk Canc Inst, Dept Canc Prevent & Control, Buffalo, NY 14263 USA

[33] Roswell Pk Canc Inst, Dept Gynecol Oncol, Buffalo, NY 14263 USA

[34] Univ Cambridge, Strangeways Res Lab, Dept Oncol, Cambridge, England

[35] Stanford Univ, Sch Med, Dept Hlth Res & Policy, Stanford, CA 94305 USA

[36] Univ S Florida, Coll Med, Epidemiol Ctr, Tampa, FL USA

[37] UCL, EGA Inst Womens Hlth, London, England

[38] Univ So Calif, Kenneth Norris Jr Comprehens Canc Ctr, Keck Sch Med, Dept Prevent Med, Los Angeles, CA 90033 USA

[39] Yale Univ, Dept Epidemiol & Publ Hlth, Sch Publ Hlth, New Haven, CT 06520 USA

[40] Yale Univ, Sch Med, New Haven, CT USA

来源：

CANCER CAUSES & CONTROL | 2013年 / 24卷 / 05期

基金：

美国国家卫生研究院; 英国医学研究理事会;

关键词：

Case-control studies; Histological type; Ovarian neoplasms; Smoking; LIFE-STYLE FACTORS; ORAL-CONTRACEPTIVES; HORMONE-THERAPY; TOBACCO USE; BORDERLINE; ASSOCIATION; TUMORS; INFLAMMATION; ALCOHOL; ADDUCTS;

D O I：

10.1007/s10552-013-0174-4

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The majority of previous studies have observed an increased risk of mucinous ovarian tumors associated with cigarette smoking, but the association with other histological types is unclear. In a large pooled analysis, we examined the risk of epithelial ovarian cancer associated with multiple measures of cigarette smoking with a focus on characterizing risks according to tumor behavior and histology. We used data from 21 case-control studies of ovarian cancer (19,066 controls, 11,972 invasive and 2,752 borderline cases). Study-specific odds ratios (OR) and 95 % confidence intervals (CI) were obtained from logistic regression models and combined into a pooled odds ratio using a random effects model. Current cigarette smoking increased the risk of invasive mucinous (OR = 1.31; 95 % CI: 1.03-1.65) and borderline mucinous ovarian tumors (OR = 1.83; 95 % CI: 1.39-2.41), while former smoking increased the risk of borderline serous ovarian tumors (OR = 1.30; 95 % CI: 1.12-1.50). For these histological types, consistent dose-response associations were observed. No convincing associations between smoking and risk of invasive serous and endometrioid ovarian cancer were observed, while our results provided some evidence of a decreased risk of invasive clear cell ovarian cancer. Our results revealed marked differences in the risk profiles of histological types of ovarian cancer with regard to cigarette smoking, although the magnitude of the observed associations was modest. Our findings, which may reflect different etiologies of the histological types, add to the fact that ovarian cancer is a heterogeneous disease.

引用

页码：989 / 1004

页数：16

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