Efficient multi-component synthesis of 1,4-benzodiazepine-3,5-diones: a Petasis-based approach

被引：38

作者：

Noushini, Saeedeh ^{[1
,2
]}

Mahdavi, Mohammad ^{[1
,2
]}

Firoozpour, Loghman ^{[3
]}

Moghimi, Setareh ^{[1
,2
]}

Shafiee, Abbas ^{[1
,2
]}

Foroumadi, Alireza ^{[1
,2
,3
]}

机构：

[1] Univ Tehran Med Sci, Fac Pharm, Dept Med Chem, Tehran, Iran

[2] Univ Tehran Med Sci, Pharmaceut Sci Res Ctr, Tehran, Iran

[3] Univ Tehran Med Sci, Drug Design & Dev Res Ctr, Tehran, Iran

来源：

TETRAHEDRON | 2015年 / 71卷 / 36期

基金：

美国国家科学基金会;

关键词：

Petasis reaction; Benzodiazepine-3,5-diones; Primary amines; Multi-component reaction; Molecular sieves; SOLID-PHASE SYNTHESIS; ONE-POT SYNTHESIS; MANNICH REACTION; ACID; DERIVATIVES; CATALYST; DESIGN; ESTERS; AMIDES; ROUTE;

D O I：

10.1016/j.tet.2015.06.060

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new design for the synthesis of 1,2-dihydro-4H-benzo[e][1,4]diazepine-3,5-diones based on Petasis reaction followed by intramolecular amidation in one-pot manner is reported. By employing different primary aromatic and aliphatic amines along with boronic acid derivatives, the desired products have been obtained at ambient temperature in moderate to good yields. (C) 2015 Elsevier Ltd. All rights reserved.

引用

页码：6272 / 6275

页数：4

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