Genome-wide DNA analysis identifies recurrent imbalances predicting outcome in chronic lymphocytic leukaemia with 17p deletion

被引：52

作者：

Forconi, Francesco ^{[1
]}

Rinaldi, Andrea ^{[2
]}

Kwee, Ivo ^{[2
,3
]}

Sozzi, Elisa ^{[1
]}

Raspadori, Donatella ^{[1
]}

Rancoita, Paola M. V. ^{[2
,3
]}

Scandurra, Marta ^{[2
]}

Rossi, Davide ^{[4
,5
]}

Deambrogi, Clara ^{[4
,5
]}

Capello, Daniela ^{[4
,5
]}

Zucca, Emanuele ^{[6
]}

Marconi, Daniela ^{[5
,7
]}

Bomben, Riccardo ^{[7
]}

Gattei, Valter

Lauria, Francesco ^{[1
]}

Gaidano, Gianluca ^{[4
,5
]}

Bertoni, Francesco ^{[2
]}

机构：

[1] Univ Siena, Dipartimento Med Clin & Sci Immunol, Sez Ematol & Trapianti, I-53100 Siena, Italy

[2] Oncol Inst So Switzerland, Expt Oncol Lab, Bellinzona, Switzerland

[3] Ist Dalle Molle Studi Intelligenza Artificiale, Manno, Switzerland

[4] Univ Piemonte Orientale Amedeo Avogadro, Dipartimento Genet Clin & Sperimentale, Div Ematol, Novara, Italy

[5] Univ Piemonte Orientale Amedeo Avogadro, BRMA, Novara, Italy

[6] Oncol Inst So Switzerland, Lymphoma Unit, Bellinzona, Switzerland

[7] IRCCS, Ctr Riferimento Oncol, Clin & Expt Oncohematol Unit, Aviano, PN, Italy

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 2008年 / 143卷 / 04期

基金：

瑞士国家科学基金会;

关键词：

chronic lymphocytic leukaemia; 17p13; deletion; TP53; genome-wide DNA profile; 250K Affymetrix; single nucleotide polymporphysms;

D O I：

10.1111/j.1365-2141.2008.07373.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Deletion of 17p (TP53) identifies a rare subset of chronic lymphocytic leukaemia (17p- CLL) with aggressive behaviour. Genome-wide DNA-profiling was performed to investigate 18 patients with 17p- CLL. All cases had multiple copy-number (CN) changes. Among the several recurrent CN changes identified, 8q24.13-q24.1-gain (MYC), 8p-loss (TNFRSF10A/B, also known as TRAIL1/2) and 2p16.1-p14-gain (REL/BCL11A) appeared frequently represented. 8p-loss and 2p16.1-p14-gain also appeared clinically relevant and predicted significant shorter time from diagnosis to treatment (8p-loss) and overall survival (8p-loss and 2p16.1-p14-gain, P < 0.05). These observations document a highly unstable genome in 17p- CLL and suggest that additional genes outside the TP53 locus may be important for tumour behaviour.

引用

页码：532 / 536

页数：5

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