Oxidative Condensations To Form Benzimidazole-Substituted Potassium Organotrifluoroborates

被引：39

作者：

Molander, Gary A. ^{[1
]}

Ajayi, Kehinde ^{[1
]}

机构：

[1] Univ Penn, Dept Chem, Roy & Diana Vagelos Labs, Philadelphia, PA 19104 USA

来源：

ORGANIC LETTERS | 2012年 / 14卷 / 16期

关键词：

CROSS-COUPLING REACTIONS; CATALYZED SYNTHESIS; ONE-POT; EFFICIENT; DERIVATIVES; CONSTRUCT; ACCESS; BONDS; METAL;

D O I：

10.1021/ol301956p

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A library of benzimidazole-substituted potassium organotrifluoroborates was prepared via the condensation of various potassium formyl-substituted aryl- and heteroaryltrifluoroborates with aromatic 1,2-diamines under oxidative conditions. The efficient Suzuki-Miyaura cross-coupling of products thus formed to various aryl and heteroaryl bromides was achieved in good yields. The method allows the facile preparation of benzimidazole-containing triaromatic products in two steps from simple potassium formyl substituted aryl- or heteroaryltrifluoroborates.

引用

页码：4242 / 4245

页数：4

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