T-cell large granular lymphocyte leukemia in a child with anemia and Crohn's disease

被引：7

作者：

Kondoh, Kensuke ^{[1
]}

Morimoto, Mizuho ^{[1
]}

Keino, Dai ^{[1
]}

Oyama, Ryo ^{[1
]}

Nagae, Chiai ^{[1
]}

Ashikaga, Tomoko ^{[1
]}

Arai, Katsuhiro ^{[2
]}

Nakazawa, Atsuko ^{[3
]}

Kinoshita, Akitoshi ^{[1
]}

机构：

[1] St Marianna Univ, Sch Med, Dept Pediat, Kawasaki, Kanagawa 2168511, Japan

[2] Natl Ctr Child Hlth & Dev, Dept Med Specialties, Div Gastroenterol, Tokyo, Japan

[3] Natl Ctr Child Hlth & Dev, Dept Pathol, Tokyo, Japan

来源：

PEDIATRICS INTERNATIONAL | 2013年 / 55卷 / 01期

关键词：

anemia; autoimmune disease; Crohn's disease; parvovirus B19; T-cell large granular lymphocyte leukemia; APLASIA; THERAPY; PATIENT; COHORT;

D O I：

10.1111/j.1442-200X.2012.03631.x

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

T-LGL leukemia has been rarely reported in children. We report a child with T-LGL leukemia who presented with anemia and went on to develop Crohn's disease. Although prednisolone treatment proved effective in the treatment of anemia, large granular lymphocyte counts increased as the doses were tapered. T-cell rearrangement studies revealed a clonal rearrangement of the TCR V/j2 gene. Concurrently, the patient developed severe diarrhea. Inflammatory changes across the upper and lower intestines led to the diagnosis of Crohn's disease. This case highlights that T-LGL leukemia could be occurred in children. Flow cytometry and/or T-cell gene rearrangement studies are recommend in patients of anemia and various kind of autoimmune diseases including Crohn's disease, even in children.

引用

页码：111 / 114

页数：4

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