Molecular and functional aspects of menstruation in the macaque

被引:28
作者
Brenner, Robert M. [1 ]
Slayden, Ov D. [1 ]
机构
[1] Oregon Hlth & Sci Univ, Div Reprod & Dev Sci, Oregon Natl Primate Res Ctr, Beaverton, OR USA
基金
美国国家卫生研究院;
关键词
Macaque; Menstruation; Model; Hormonal control; Menstrual blood loss; Endometrium; Cervix; Heavy menstrual bleeding; ENDOMETRIAL MATRIX METALLOPROTEINASES; GROWTH-FACTOR EXPRESSION; CELL-PROLIFERATION; PROGESTERONE WITHDRAWAL; EXTRACELLULAR-MATRIX; ESTROGEN-RECEPTORS; GENE-EXPRESSION; MACACA-MULATTA; RHESUS-MONKEY; CYCLE;
D O I
10.1007/s11154-012-9225-5
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Much of our understanding of the molecular control of menstruation arises from laboratory models that experimentally recapitulate some, but not all, aspects of uterine bleeding observed in women. These models include: in vitro culture of endometrial explants or isolated endometrial cells, transplantation of human endometrial tissue into immunodeficient mice and the induction of endometrial breakdown in appropriately pretreated mice. Each of these models has contributed to our understanding of molecular and cellular mechanisms of menstruation, but nonhuman primates, especially macaques, are the animal model of choice for evaluating therapies for menstrual disorders. In this chapter we review some basic aspects of menstruation, with special emphasis on the macaque model and its relevance to the clinical issues of irregular and heavy menstrual bleeding (HMB).
引用
收藏
页码:309 / 318
页数:10
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