The enemy within us: lessons from the 2011 European Escherichia coli O104:H4 outbreak

被引：184

作者：

Karch, Helge ^{[2
]}

Denamur, Erick ^{[3
]}

Dobrindt, Ulrich ^{[2
]}

Finlay, B. Brett ^{[4
]}

Hengge, Regine ^{[5
]}

Johannes, Ludgers ^{[6
]}

Ron, Eliora Z. ^{[7
]}

Tonjum, Tone ^{[8
]}

Sansonetti, Philippe J. ^{[9
,10
]}

Vicente, Miguel ^{[1
]}

机构：

[1] Ctr Nacl Biotecnol CNB CSIC, Madrid, Spain

[2] Univ Munster, Inst Hyg, Munster, Germany

[3] Univ Paris Diderot, INSERM, UMR S 722, Paris, France

[4] Univ British Columbia, Michael Smith Labs, Dept Microbiol & Immunol, Vancouver, BC V5Z 1M9, Canada

[5] Free Univ Berlin, Inst Biol Mikrobiol, Berlin, Germany

[6] Inst Curie, Traff Signaling & Delivery Lab, Curie CNRS UMR144, Paris, France

[7] Tel Aviv Univ, Fac Life Sci, Dept Mol Microbiol & Biotechnol, MIGAL Galil Res Ctr, Tel Aviv, Israel

[8] Univ Oslo, Ctr Mol Biol & Neurosci, Inst Microbiol, Oslo, Norway

[9] Inst Pasteur, Unite Pathogenie Microbienne Mol, Paris, France

[10] Inst Pasteur, Unite INSERM 786, Paris, France

来源：

EMBO MOLECULAR MEDICINE | 2012年 / 4卷 / 09期

基金：

欧洲研究理事会;

关键词：

Escherichia coli; HUS; infection; O104:H4; outbreak; HEMOLYTIC-UREMIC SYNDROME; SHIGA-TOXIN; GERMAN OUTBREAK; STRAIN; ANTIBIOTICS; ECULIZUMAB; INFECTION; PROTECTS; GENE; HUS;

D O I：

10.1002/emmm.201201662

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

In response to the 2011 European health alert caused by a pathogenic Escherichia coli O104:H4 outbreak, the European Academy of Microbiology (EAM), established by the Federation of European Microbiological Societies (FEMS), convened a meeting in Paris on November 30th, 2011 on EHEC infection and control attended by world renowned experts in pathogenic E. coli. The major aims of this group were to review the scientific issues raised by the outbreak, to assess the handling of the crisis at the scientific and political levels, and to propose future actions. Several conclusions, which will have impact on future potential E. coli outbreaks, are outlined here.

引用

页码：841 / 848

页数：8

共 35 条

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Allen KJ, 2011, CAN J VET RES, V75, P98

[2] French cattle is not a reservoir of the highly virulent enteroaggregative Shiga toxin-producing Escherichia coli of serotype O104:H4 [J].