Evaluation of 'east-to-west' ether-forming strategies for the total synthesis of maoecrystal V

被引：23

作者：

Lazarski, Kiel E. ^{[1
]}

Akpinar, Berkcan ^{[1
]}

Thomson, Regan J. ^{[1
]}

机构：

[1] Northwestern Univ, Dept Chem, Evanston, IL 60208 USA

来源：

TETRAHEDRON LETTERS | 2013年 / 54卷 / 07期

关键词：

Maoecrystal V; Etherification; Oxy-1,4-addition; INTRAMOLECULAR HYDROGEN ABSTRACTION; GENERATION; FUNCTIONALIZATION; HYDROXYLATION; EFFICIENT;

D O I：

10.1016/j.tetlet.2012.11.135

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Model systems that evaluated different approaches to construct the central ether ring of maoecrystal V are described. Our first model systems attempted the ether formation using C-H functionalization reactions, which led to interesting rearrangements but none of the desired ether product. An intramolecular conjugate addition strategy was then explored that successfully formed the targeted C-O bond but resulted in the undesired stereochemistry. (c) 2012 Elsevier Ltd. All rights reserved.

引用

页码：635 / 637

页数：3

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