The risk factors for diabetic peripheral neuropathy: A meta-analysis

被引:137
作者
Liu, Xiuxiu [1 ]
Xu, Yuyan [1 ]
An, Miaomiao [1 ]
Zeng, Qibing [1 ]
机构
[1] Guizhou Med Univ, Key Lab Environm Pollut Monitoring & Dis Control, Minist Educ, Dept Toxicol,Sch Publ Hlth, Guiyang, Guizhou, Peoples R China
基金
国家重点研发计划;
关键词
VITAMIN-D DEFICIENCY; GLYCEMIC VARIABILITY; PREVALENCE; POLYNEUROPATHY; PAIN; EPIDEMIOLOGY; SEVERITY; DISEASE;
D O I
10.1371/journal.pone.0212574
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Diabetic peripheral neuropathy (DPN), the most common chronic complication of diabetes, has become an important public health crisis worldwide. Given that DPN is extremely difficult to treat, determining its risk factors and controlling it at an early stage is critical to preventing its serious consequences and the burden of social disease. Current studies suggest that the risk factors for diabetic peripheral neuropathy are the duration of diabetes, age, glycosylated hemoglobin A1c (HbA1c), diabetic retinopathy (DR), smoking, and body mass Index (BMI). However, most of the aforementioned studies are cross-sectional, and the sample sizes are very limited, so the strength of causal reasoning is relatively low. The current study systematically evaluated DPN's influencing factors in patients with type 2 diabetes using evidence-based medicine. Overall, 16 included studies (14 cross-sectional studies and 2 case-control studies including 12,116 cases) that conformed to the present criteria were included in the final analysis. The results suggested that the duration of diabetes (MD 2.5, 95% CI 1.71 similar to 3.29), age (MD 4.00, 95% CI 3.05 similar to 4.95), HbA1c (MD 0.48, 95% CI 0.33 similar to 0.64), and DR (OR 2.34, 95% CI 1.74 similar to 3.16) are associated with significantly increased risks of DPN among diabetic patients, while BMI, smoking, total triglyceride (TG), and total cholesterol (TC) did not indicate any risks of increasing DPN. The findings provide a scientific basis for a further understanding of the causes of type 2 diabetes complicated with peripheral neuropathy and the improvement of preventive strategies. The next step is to conduct further high-quality prospective cohort studies to validate this paper's findings.
引用
收藏
页数:16
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