Membrane hemifusion: Crossing a chasm in two leaps

被引:278
作者
Chernomordik, LV [1 ]
Kozlov, MM
机构
[1] NICHHD, Sect Membrane Biol, Lab Cellular & Mol Biophys, Sect Membrane Biol,NIH, Bethesda, MD 20892 USA
[2] Tel Aviv Univ, Sackler Fac Med, Dept Physiol & Pharmacol, IL-69978 Tel Aviv, Israel
关键词
D O I
10.1016/j.cell.2005.10.015
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
During membrane fusion, the outer leaflets of the two membranes merge first, whereas the distal membrane leaflets remain separate until the opening of a fusion pore. This intermediate stage, called hemifusion, is a critical event shared by exocytosis, protein trafficking, and viral entry.
引用
收藏
页码:375 / 382
页数:8
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