The Treg/Th17 cell ratio is reduced in the skin lesions of patients with pyoderma gangrenosum

被引：59
作者：
Caproni, M. [1 ]
Antiga, E. [1 ]
Volpi, W. [1 ]
Verdelli, A. [1 ]
Venegoni, L. [2 ]
Quaglino, P. [3 ]
Fabbri, P. [1 ]
Marzano, A. V. [2 ]
机构：
[1] Univ Florence, Dept Surg & Translat Med, Dermatol Sect, I-50125 Florence, Italy
[2] Univ Milan, Dipartimento Fisiopatol Med Chirurg & Trapianti, Unita Operat Dermatol, Osped Maggiore Policlin,IRCCS Fdn Ca Granda, Milan, Italy
[3] Univ Turin, Dept Biomed Sci & Human Oncol, Dermatol Clin 1, I-10124 Turin, Italy
来源：
BRITISH JOURNAL OF DERMATOLOGY | 2015年 / 173卷 / 01期
关键词：
REGULATORY T-CELLS; MATRIX METALLOPROTEINASES; ATOPIC-DERMATITIS; SWEETS-SYNDROME; DISEASES; CYTOKINES; USTEKINUMAB; TACROLIMUS; EXPRESSION;
D O I：
10.1111/bjd.13670
中图分类号：
R75 [皮肤病学与性病学];
学科分类号：
100206 ;
摘要：
引用
收藏
页码：275 / 278
页数：4
相关论文
共 15 条
  • [1] Agarwal S, 2008, J RHEUMATOL, V35, P515
  • [2] Regulatory T cells in the skin lesions and blood of patients with systemic sclerosis and morphoea
    Antiga, E.
    Quaglino, P.
    Bellandi, S.
    Volpi, W.
    Del Bianco, E.
    Comessatti, A.
    Osella-Abate, S.
    De Simone, C.
    Marzano, A.
    Bernengo, M. G.
    Fabbri, P.
    Caproni, M.
    [J]. BRITISH JOURNAL OF DERMATOLOGY, 2010, 162 (05) : 1056 - 1063
  • [3] Mechanisms of impaired regulation by CD4+CD25+FOXP3+ regulatory T cells in human autoimmune diseases
    Buckner, Jane Hoyt
    [J]. NATURE REVIEWS IMMUNOLOGY, 2010, 10 (12) : 849 - 859
  • [4] What Do Autoinflammatory Syndromes Teach About Common Cutaneous Diseases Such as Pyoderma Gangrenosum? A Commentary
    Butler, Daniel
    Shinkai, Kanade
    [J]. DERMATOLOGIC CLINICS, 2013, 31 (03) : 427 - +
  • [5] The comparative effects of tacrolimus and hydrocortisone in adult atopic dermatitis: an immunohistochemical study
    Caproni, M.
    Torchia, D.
    Antiga, E.
    Terranova, M.
    Volpi, W.
    Del Bianco, E.
    D'Agata, A.
    Fabbri, P.
    [J]. BRITISH JOURNAL OF DERMATOLOGY, 2007, 156 (02) : 312 - 319
  • [6] The effects of tacrolimus ointment on regulatory T lymphocytes in atopic dermatitis
    Caproni, Marzia
    Torchia, Daniele
    Antiga, Emiliano
    Volpi, Walter
    Del Bianco, Elena
    Fabbri, Paolo
    [J]. JOURNAL OF CLINICAL IMMUNOLOGY, 2006, 26 (04) : 370 - 375
  • [7] Genotype, phenotype, and clinical course in five patients with PAPA syndrome (pyogenic sterile arthritis, pyoderma gangrenosum, and acne)
    Demidowich, Andrew P.
    Freeman, Alexandra F.
    Kuhns, Douglas B.
    Aksentijevich, Ivona
    Gallin, John I.
    Turner, Maria L.
    Kastner, Daniel L.
    Holland, Steven M.
    [J]. ARTHRITIS AND RHEUMATISM, 2012, 64 (06): : 2022 - 2027
  • [8] Foxp3+ Regulatory T Cells, Th17 Effector Cells, and Cytokine Environment in Inflammatory Bowel Disease
    Eastaff-Leung, Nicola
    Mabarrack, Nicholas
    Barbour, Angela
    Cummins, Adrian
    Barry, Simon
    [J]. JOURNAL OF CLINICAL IMMUNOLOGY, 2010, 30 (01) : 80 - 89
  • [9] Inflammatory Bowel Disease and Mutations Affecting the Interleukin-10 Receptor
    Glocker, Erik-Oliver
    Kotlarz, Daniel
    Boztug, Kaan
    Gertz, E. Michael
    Schaeffer, Alejandro A.
    Noyan, Fatih
    Perro, Mario
    Diestelhorst, Jana
    Allroth, Anna
    Murugan, Dhaarini
    Haetscher, Nadine
    Pfeifer, Dietmar
    Sykora, Karl-Walter
    Sauer, Martin
    Kreipe, Hans
    Lacher, Martin
    Nustede, Rainer
    Woellner, Cristina
    Baumann, Ulrich
    Salzer, Ulrich
    Koletzko, Sibylle
    Shah, Neil
    Segal, Anthony W.
    Sauerbrey, Axel
    Buderus, Stephan
    Snapper, Scott B.
    Grimbacher, Bodo
    Klein, Christoph
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2009, 361 (21) : 2033 - 2045
  • [10] Severely recalcitrant pyoderma gangrenosum successfully treated with ustekinumab
    Goldminz, Ari M.
    Botto, Nina C.
    Gottlieb, Alice B.
    [J]. JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 2012, 67 (05) : E237 - E238
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