Synthesis, crystal structures, and anti-drug-resistant Staphylococcus aureus activities of novel 4-hydroxycoumarin derivatives

被引：30

作者：

Li, Ming-kai ^{[1
]}

Li, Jing ^{[2
]}

Liu, Bao-hui ^{[3
]}

Zhou, Ying ^{[1
]}

Li, Xia ^{[4
]}

Xue, Xiao-yan ^{[1
]}

Hou, Zheng ^{[1
]}

Luo, Xiao-xing ^{[1
]}

机构：

[1] Fourth Mil Med Univ, Dept Pharmacol, Sch Pharm, Xian 710032, Peoples R China

[2] Xian Univ Arts & Sci, Sch Chem & Chem Engn, Xian, Peoples R China

[3] Fourth Mil Med Univ, Dept Cardiac Surg, Xijing Hosp, Xian 710032, Peoples R China

[4] Fourth Mil Med Univ, Dept Neurosurg, Xijing Hosp, Xian 710032, Peoples R China

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 2013年 / 721卷 / 1-3期

基金：

中国国家自然科学基金;

关键词：

4-Hydroxycoumarin; Single crystal; Staphylococcus aureus; Minimum inhibitory concentration; COMMUNITY; SUSCEPTIBILITY; BISCOUMARIN; HOSPITALS; OUTBREAK;

D O I：

10.1016/j.ejphar.2013.09.040

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Four novel 4-hydroxycoumarin derivatives (4-MBH, 3-MBH, 4-MDT and 3-MDT) were successfully synthesized and their structures were verified by single-crystal X-ray crystallography. All target compounds were evaluated for their in vitro antibacterial activity against Staphylococcus aureus (S. aureus ATCC 29213), methicillin-resistant S. aureus (MRSA XJ 75302), vancomycin-intermediate S. aureus (Mu50 ATCC 700699), and USA 300 (Los Angeles County clone, LAC). The minimum inhibitory concentration and time-kill curves were obtained for the test compounds and antibiotics. Among the tested compounds, 3-MBH showed the most potent antibacterial activities. (C) 2013 Elsevier B.V. All rights reserved,

引用

页码：151 / 157

页数：7

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