Cell-Imprinted Substrates Direct the Fate of Stem Cells

被引：100

作者：

Mahmoudi, Morteza ^{[1
,2
,3
]}

Bonakdar, Shahin ^{[1
]}

Shokrgozar, Mohammad A. ^{[1
]}

Aghaverdi, Haniyeh ^{[2
,3
]}

Hartmann, Raimo ^{[4
]}

Pick, Andre ^{[4
]}

Witte, Gregor ^{[4
]}

Parak, Wolfgang J. ^{[4
,5
]}

机构：

[1] Pasteur Inst Iran, Natl Cell Bank, Tehran 13164, Iran

[2] Univ Tehran Med Sci, Fac Pharm, Dept Nanotechnol, Lab NanoBio Interact, Tehran 13164, Iran

[3] Univ Tehran Med Sci, Fac Pharm, Nanotechnol Res Ctr, Tehran 13164, Iran

[4] Univ Marburg, Fachbereich Phys, D-35037 Marburg, Germany

[5] CIC Biomagune, San Sebastian 20009, Spain

来源：

ACS NANO | 2013年 / 7卷 / 10期

关键词：

stem cells; biomimicking; cell morphology; cell fate; differentiation; smart substrates; GROWTH-FACTOR; DIFFERENTIATION; NANOSCALE; BIOMATERIALS; MATRIX; SURFACE; NICHE;

D O I：

10.1021/nn403844q

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Smart nanoenvironments were obtained by cell-imprinted substrates based on mature and dedifferentiated chondrocytes as templates. Rabbit adipose derived mesenchymal stem cells (ADSCs) seeded on these cell-imprinted substrates were driven to adopt the specific shape (as determined in terms of cell morphology) and molecular characteristics (as determined In terms of gene expression) of the cell types which had been used as template for the cell-imprinting. This method might pave the way for a reliable, efficient, and cheap way of controlling stem cell differentiation. Data also suggest that besides residual cellular fragments, which are presented on the template surface, the imprinted topography of the templates plays a role in the differentiation of the stem cells.

引用

页码：8379 / 8384

页数：6

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