A facile fabrication of upconversion luminescent and mesoporous core- shell structured β-NaYF4:Yb3+, Er3+@mSiO2 nanocomposite spheres for anti-cancer drug delivery and cell imaging

被引：103

作者：

Li, Chunxia ^{[1
]}

Hou, Zhiyao ^{[1
]}

Dai, Yunlu ^{[1
]}

Yang, Dongmei ^{[1
]}

Cheng, Ziyong ^{[1
]}

Ma, Ping'an ^{[1
]}

Lin, Jun ^{[1
]}

机构：

[1] Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Rare Earth Resource Utilizat, Changchun 13002, Peoples R China

来源：

BIOMATERIALS SCIENCE | 2013年 / 1卷 / 02期

基金：

中国国家自然科学基金;

关键词：

SILICA NANOPARTICLES; MAGNETIC-RESONANCE; POROUS NAYF4/YB3+; UNIFORM; BIOCOMPATIBILITY; BIODISTRIBUTION; NANOCRYSTALS; FLUORESCENCE; NANOSPHERES; NANOPROBES;

D O I：

10.1039/c2bm00087c

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

0805 ; 080501 ; 080502 ;

摘要：

Upconversion luminescent beta-NaYF4:Yb3+, Er3+ nanoparticles (UCNPs) were encapsulated with uniform mesoporous silica shells, which were further modified with poly(ethylene glycol) (PEG) and cancer-targeting ligand folic acid (FA), resulting in the formation of water-dispersible and biologically functionalized core-shell structured UCNPs@mSiO(2) nanoparticles with an overall average size of around 80 nm. The obtained multifunctional nanocomposite spheres can be performed as an anti-cancer drug delivery carrier and applied for cell imaging. It is found that anti-cancer drug doxorubicin hydrochloride (DOX) can be absorbed into UCNPs@mSiO(2)-PEG/FA nanospheres and released in a pH-sensitive pattern. In vitro cell cytotoxicity tests on cancer cells verified that DOX-loaded UCNPs@mSiO(2)-PEG/FA nanospheres exhibited greater cytotoxicity with respect to free DOX and DOX-loaded UCNPs@mSiO(2)-PEG at the same concentrations, owing to the increase of cell uptake of anti-cancer drug delivery vehicles mediated by the FA receptor. Moreover, the upconversion luminescence image of UCNPs@mSiO(2)-PEG/FA taken up by cells shows green emission under 980 nm infrared laser excitation, making the UCNPs@mSiO(2)-PEG/FA nanocomposite spheres promising candidates as bioimaging agents. These findings highlight the promise of the highly versatile multifunctional nanoparticles for simultaneous imaging and therapeutic applications.

引用

页码：213 / 223

页数：11

共 75 条

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