Metformin and aspirin: some "new" cancer treatments? Prevention and anti-tumoral activity

被引：1

作者：

Arrondeau, J. ^{[1
]}

Bost, F. ^{[2
]}

机构：

[1] Hop Cochin, Serv Oncol Med, F-75005 Paris, France

[2] Univ Nice Sophia Antipolis, INSERM, U1065, Equipe 7, F-06204 Nice 03, France

来源：

ONCOLOGIE | 2013年 / 15卷 / 09期

关键词：

Cancer; Metformin; Aspirin; AMPK/mTOR; Cyclooxygenase; NONSTEROIDAL ANTIINFLAMMATORY DRUGS; ACTIVATED PROTEIN-KINASE; LOW-DOSE ASPIRIN; LONG-TERM USE; COLORECTAL-CANCER; RANDOMIZED-TRIAL; BREAST-CANCER; PROSTATE-CANCER; IN-VIVO; RISK;

D O I：

10.1007/s10269-013-2319-1

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Recently, old drugs such as the anti-diabetic agent metformin and aspirin have been found to display anti-tumoral properties. Indeed, there are more and more evidence showing that these drugs affect cancer cell proliferation and decrease tumor growth in various animal models. In this review, we summarize fundamental, pre-clinical, and clinical studies which describe metformin and aspirin action in cancer.

引用

页码：480 / 489

页数：10

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