Migraine affects white-matter tract integrity: A diffusion-tensor imaging study

被引:53
作者
Chong, Catherine D. [1 ]
Schwedt, Todd J. [1 ]
机构
[1] Mayo Clin, Dept Neurol, Phoenix, AZ 85054 USA
基金
美国国家卫生研究院;
关键词
Migraine; pain; neuroimaging; white matter; fibertracts; diffusion-tensor imaging; GRAY-MATTER; BRAIN; AURA; MICROSTRUCTURE; ABNORMALITIES; SEGMENTATION; MODULATION; THALAMUS; PAIN;
D O I
10.1177/0333102415573513
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Background Specific white-matter tract alterations in migraine remain to be elucidated. Using diffusion tensor imaging (DTI), this study investigated whether the integrity of white-matter tracts that underlie regions of the pain matrix is altered in migraine and interrogated whether the number of years lived with migraine modifies fibertract structure. Methods Global probabilistic tractography was used to assess the anterior thalamic radiations, the corticospinal tracts and the inferior longitudinal fasciculi in 23 adults with migraine and 18 healthy controls. Results Migraine patients show greater mean diffusivity (MD) in the left and right anterior thalamic radiations, the left corticospinal tract, and the right inferior longitudinal fasciculus tract. Migraine patients also show greater radial diffusivity (RD) in the left anterior thalamic radiations, the left corticospinal tract as well as the left and right inferior longitudinal fasciculus tracts. No group fractional anisotropy (FA) differences were identified for any tracts. Migraineurs showed a positive correlation between years lived with migraine and MD in the right anterior thalamic radiations (r=0.517; p=0.012) and the left corticospinal tract (r=0.468; p=0.024). Conclusion Results indicate that white-matter integrity is altered in migraine and that longer migraine history is positively correlated with greater alterations in tract integrity.
引用
收藏
页码:1162 / 1171
页数:10
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