Management of Relapsed Diffuse Large B-cell Lymphoma

被引：23

作者：

Crump, Michael ^{[1
]}

机构：

[1] Princess Margaret Canc Ctr, Div Med Oncol & Hematol, 610 Univ Ave,Room 5-209, Toronto, ON M5G 2M9, Canada

来源：

HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA | 2016年 / 30卷 / 06期

关键词：

Relapsed/refractory DLBCL; Autologous transplant; Salvage chemotherapy; Prognosis; CD20; antibody; NON-HODGKIN-LYMPHOMA; NERVOUS-SYSTEM LYMPHOMA; HIGH-DOSE CHEMOTHERAPY; MABTHERA INTERNATIONAL TRIAL; BONE-MARROW-TRANSPLANTATION; MULTICENTER PHASE-II; ELDERLY-PATIENTS; CNS RELAPSE; AGGRESSIVE LYMPHOMA; PLUS RITUXIMAB;

D O I：

10.1016/j.hoc.2016.07.004

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Second-line therapy options for patients with diffuse large B-cell lymphoma (DLBCL) that is refractory to, or relapses after, current rituximab-containing primary therapy continue to evolve. For younger patients, salvage therapy followed by intensive therapy and autologous stem cell transplant (ASCT) remains the treatment of choice for those with chemotherapy-sensitive disease. Combination therapy may be used for those who are not candidates for ASCT. In contrast, patients with DLBCL refractory to 2 lines of therapy have a very poor prognosis and generally short survival, and should be carefully considered for participation in clinical trials of novel approaches.

引用

页码：1195 / +

页数：20

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