Differential effects of grape seed extract against human colorectal cancer cell lines: The intricate role of death receptors and mitochondria

被引：26

作者：

Derry, Molly ^{[1
]}

Raina, Komal ^{[1
]}

Agarwal, Rajesh ^{[1
,2
]}

Agarwal, Chapla ^{[1
,2
]}

机构：

[1] Univ Colorado, Skaggs Sch Pharm & Pharmaceut Sci, Dept Pharmaceut Sci, Aurora, CO 80045 USA

[2] Univ Colorado, Ctr Canc, Aurora, CO 80045 USA

来源：

CANCER LETTERS | 2013年 / 334卷 / 01期

关键词：

Grape seed extract; Apoptosis; Death receptors; Colorectal cancer; Mitochondrial membrane potential; TRAIL-INDUCED APOPTOSIS; CARCINOMA DU145 CELLS; CYCLE ARREST; MEDIATED APOPTOSIS; ENDOTHELIAL-CELLS; CASPASE-8; GENE; BREAST-CANCER; IN-VITRO; RESISTANCE; ACTIVATION;

D O I：

10.1016/j.canlet.2012.12.015

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Failure of anti-cancer therapy in colorectal cancer (CRC) cells involves resistance to death mechanisms. We investigated grape seed extract (GSE) ability to target CRC cells and delineated the mechanisms involved in GSE-induced CRC cell death. GSE selectively induced apoptotic death in human CRC cells; efficacy increased as the metastatic potential of the cancer cells increased. Oxidative stress, loss of mitochondrial membrane potential, modulation of pro- and anti-apoptotic proteins, and involvement of both caspase-dependent/independent apoptotic pathways contributed to GSE-induced CRC cell death. GSE intervention may serve as a multi-targeted CRC therapeutic capable of inducing selective cancer cell death. (C) 2012 Elsevier Ireland Ltd. All rights reserved.

引用

页码：69 / 78

页数：10

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