Cytotoxic Alkaloids from the Whole Plants of Zephyranthes candida

被引：81

作者：

Luo, Zengwei ^{[1
]}

Wang, Fuqian ^{[1
]}

Zhang, Jinwen ^{[2
]}

Li, Xingyao ^{[3
]}

Zhang, Mengke ^{[1
]}

Hao, Xincai ^{[1
]}

Xue, Yongbo ^{[1
]}

Li, Yan ^{[3
]}

Horgen, F. David ^{[4
]}

Yao, Guangmin ^{[1
]}

Zhang, Yonghui ^{[1
]}

机构：

[1] Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Pharm, Hubei Key Lab Nat Med Chem & Resource Evaluat, Wuhan 430030, Peoples R China

[2] Huazhong Univ Sci & Technol, Tongji Hosp Affiliated, Tongji Med Coll, Wuhan 430030, Peoples R China

[3] Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China

[4] Hawaii Pacific Univ, Dept Nat Sci, Lab Marine Biol Chem, Kaneohe, HI 96744 USA

来源：

JOURNAL OF NATURAL PRODUCTS | 2012年 / 75卷 / 12期

关键词：

AMARYLLIDACEAE ALKALOIDS; SPREKELIA-FORMOSISSIMA; LYCORINE; APOPTOSIS;

D O I：

10.1021/np3005425

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Seven new alkaloids, N-methylhemeanthidine chloride (1), N-methyl-5,6-dihydroplicane (5), O-methylnerinine (6), N-ethoxycarbonylethylcrinasiadine (7), N-ethoxy-carbonylpropylcrinasiadine (8), N-phenethylcrinasiadine (9), and N-isopentylcrinasiadine (10), together with eight known alkaloids, hemeanthamin (2), 3-epimacronine (3), (+)-tazettine (4), N-methylcrinasiadine (11), trisphaeridine (12), 5,6-dihydrobicolorine (13), lycorine (14), and nigragillin (15), were isolated from the whole plants of Zephyranthes candida. The structures of the new compounds were established by spectroscopic data interpretation, with single-crystal X-ray diffraction analysis performed on 1. The absolute configuration of 3-epimacronine (3) was determined by single-crystal X-ray diffraction analysis with Cu K alpha irradiation. Compounds 1-15 were evaluated for their in vitro cytotoxicity against five human cancer cell lines and the Beas-2B immortalized (noncancerous) human bronchial epithelial cell line. Compounds 1, 2, 9, and 14 exhibited cytotoxicity with IC50 values ranging from 0.81 to 13 mu M with selectivity indices as high as 10 when compared to the Beas-2B cell line.

引用

页码：2113 / 2120

页数：8

共 36 条

[1] New crinine-type alkaloids with inhibitory effect on induction of inducible nitric oxide synthase from Crinum yemense [J].