Synthesis and characterization of graphene nanosheets attached to spiky MnO2 nanospheres and its application in ultrasensitive immunoassay

被引：65

作者：

Zhang, Yan ^{[1
]}

Su, Min ^{[1
]}

Ge, Lei ^{[1
]}

Ge, Shenguang ^{[2
]}

Yu, Jinghua ^{[1
]}

Song, Xianrang ^{[3
]}

机构：

[1] Univ Jinan, Sch Chem & Chem Engn, Key Lab Chem Sensing & Anal, Shandong Univ, Jinan 250022, Peoples R China

[2] Univ Jinan, Shandong Prov Key Lab Preparat & Measurement Bldg, Jinan 250022, Peoples R China

[3] Shandong Tumor Hosp, Canc Res Ctr, Jinan 250012, Peoples R China

来源：

CARBON | 2013年 / 57卷

关键词：

MANGANESE OXIDE NANOSTRUCTURES; ELECTROCHEMICAL IMMUNOSENSOR; HORSERADISH-PEROXIDASE; FACILE SYNTHESIS; ELECTROCHEMILUMINESCENCE; PERFORMANCE; FABRICATION; NANOPARTICLES; ELECTRODE; COMPOSITE;

D O I：

10.1016/j.carbon.2013.01.012

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

An easy approach was reported to synthesize graphene nanosheets attached to spiky MnO2 nanospheres (GS/MnO2) which showed good catalytic activity, electrical conductivity, solubility and processability. The synthetic method was efficient, green and controllable with graphene oxide reduced and MnO2 nanospheres formed in one step. The obtained material was further characterized and used as carriers for signal antibodies (Ab(2)) to produce an electrochemiluminescent immunosensor based on prepared nanoporous gold-graphene nanosheets platform. With a sandwich-type immunoassay format, the amount of GS/MnO2 labeled Ab(2) went up with the increased concentration of antigens in the sample. Such immunosensor exhibited high sensitivity in the detection of carcinoembryonic antigen in serum samples. (c) 2013 Elsevier Ltd. All rights reserved.

引用

页码：22 / 33

页数：12

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