Global increase in DNA methylation in patients with myelodysplastic syndrome

被引:23
作者
Roemermann, D. [1 ]
Hasemeier, B. [1 ]
Metzig, K. [1 ]
Goehring, G. [2 ]
Schlegelberger, B. [2 ]
Laenger, F. [1 ]
Kreipe, H. [1 ]
Lehmann, U. [1 ]
机构
[1] Med Hochschule Hannover, Inst Pathol, Hannover, Germany
[2] Med Hochschule Hannover, Inst Cell & Mol Pathol, Hannover, Germany
关键词
D O I
10.1038/leu.2008.76
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
[No abstract available]
引用
收藏
页码:1954 / 1956
页数:4
相关论文
共 7 条
[1]   Quantitative high-resolution CpG island mapping with Pyrosequencing™ reveals disease-specific methylation patterns of the CDKN2B gene in Myelodysplastic syndrome and myeloid leukemia [J].
Brakensiek, Kai ;
Wingen, Luzie U. ;
Langer, Florian ;
Kreipe, Hans ;
Lehmann, Ulrich .
CLINICAL CHEMISTRY, 2007, 53 (01) :17-23
[2]   DNA methylation and cancer [J].
Das, PM ;
Singal, R .
JOURNAL OF CLINICAL ONCOLOGY, 2004, 22 (22) :4632-4642
[3]   Induction of tumors in mice by genomic hypomethylation [J].
Gaudet, F ;
Hodgson, JG ;
Eden, A ;
Jackson-Grusby, L ;
Dausman, J ;
Gray, JW ;
Leonhardt, H ;
Jaenisch, R .
SCIENCE, 2003, 300 (5618) :489-492
[4]   DNA methyltransferase and histone deacetylase inhibitors in the treatment of Myelodysplastic syndromes [J].
Griffiths, Elizabeth A. ;
Gore, Steven D. .
SEMINARS IN HEMATOLOGY, 2008, 45 (01) :23-30
[5]   LUMA (LUminometric Methylation Assay) -: A high throughput method to the analysis of genomic DNA methylation [J].
Karimi, Mohsen ;
Johansson, Sofia ;
Stach, Dirk ;
Corcoran, Martin ;
Grander, Dan ;
Schalling, Martin ;
Bakalkin, Georgy ;
Lyko, Frank ;
Larsson, Catharina ;
Ekstrom, Tomas J. .
EXPERIMENTAL CELL RESEARCH, 2006, 312 (11) :1989-1995
[6]   Hypomethylation of L1 retrotransposons in colorectal cancer and adjacent normal tissue [J].
Suter, CM ;
Martin, DI ;
Ward, RL .
INTERNATIONAL JOURNAL OF COLORECTAL DISEASE, 2004, 19 (02) :95-101
[7]   A simple method for estimating global DNA methylation using bisulfite PCR of repetitive DNA elements -: art. no. e38 [J].
Yang, AS ;
Estécio, MRH ;
Doshi, K ;
Kondo, Y ;
Tajara, EH ;
Issa, JPJ .
NUCLEIC ACIDS RESEARCH, 2004, 32 (03) :e38