Optimization of ultrasound-assisted extraction of phenolic compounds from Cimicifugae rhizoma with response surface methodology

被引：16

作者：

Liu, Lin ^{[1
]}

Shen, Bao-Jia ^{[2
,3
,4
]}

Xie, Dong-Hao ^{[1
]}

Cai, Bao-Chang ^{[2
,3
,4
]}

Qin, Kun-Ming ^{[2
,3
,4
]}

Cai, Hao ^{[2
,4
]}

机构：

[1] Dahua Hosp, Dept Pharm, Shanghai 200237, Peoples R China

[2] Nanjing Univ Chinese Med, Engn Res Ctr, Minist Educ Standardizat Chinese Med Proc, Nanjing 210029, Jiangsu, Peoples R China

[3] Nanjing Haichang Chinese Med Grp Co Ltd, Nanjing 210061, Jiangsu, Peoples R China

[4] Key Lab State Adm TCM Standardizat Chinese Med Pr, Nanjing 210023, Jiangsu, Peoples R China

来源：

PHARMACOGNOSY MAGAZINE | 2015年 / 11卷 / 44期

关键词：

Cimicifugae Rhizome; response surface methodology; phenolic compounds; ultrasound-assisted extraction; SUPERCRITICAL-FLUID EXTRACTION; PRESSURIZED LIQUID EXTRACTION; BIPHENYL CYCLOOCTENE LIGNANS; SCHISANDRA-CHINENSIS BAILL; BEHNKEN STATISTICAL DESIGN; ANTIOXIDANT; POLYSACCHARIDES; ANTHOCYANINS; CONSTITUENTS; SOLVENT;

D O I：

10.4103/0973-1296.165545

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Background: Cimicifugae rhizoma was a Ranunculaceae herb belonging to the composite family, and the roots of C. rhizoma have been widely used in tradition Chinese medicine. Materials and Methods: Ultrasound-assisted extraction (UAE) of phenolic compounds from C. rhizoma. Caffeic acid (CA), isoferulic acid (IA), ferulic acid (FA), and total phenols were quantified by high-performance liquid chromatography-diode array detection and ultraviolet-visible spectrophotometer. Effects of several experimental parameters, such as ultrasonic power (W), extraction temperature (degrees C), and ethanol concentration (%) on extraction efficiencies of phenolic compounds from C. rhizoma were evaluated. Results: The results showed that the optimal UAE condition was obtained with ultrasonic power of 377.35 W, extraction temperature of 70 degrees C, and ethanol concentration of 58.37% for total phenols, and ultrasonic power of 318.28 W, extraction temperature of 59.65 degrees C, and ethanol concentration of 64.43% for combination of CA, IA, FA. Conclusions: The experimental values under optimal conditions were in good consistent with the predicted values, which suggested UAE is more efficient for the extraction of phenolic compounds from plant materials.

引用

页码：682 / 689

页数：8

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