Mechanisms of stress resistance and gene regulation in the radioresistant bacterium Deinococcus radiodurans

被引：30

作者：

Agapov, A. A. ^{[1
,2
]}

Kulbachinskiy, A. V. ^{[1
,2
]}

机构：

[1] Russian Acad Sci, Inst Mol Genet, Moscow 123182, Russia

[2] Moscow MV Lomonosov State Univ, Fac Biol, Moscow 119991, Russia

来源：

BIOCHEMISTRY-MOSCOW | 2015年 / 80卷 / 10期

基金：

俄罗斯科学基金会;

关键词：

Deinococcus radiodurans; radioresistance; DNA damage; oxidative stress; regulation of gene expression; transcription; RNA polymerase; DNA-BINDING-PROTEIN; RNA-POLYMERASE BACKTRACKING; IRON-SULFUR CLUSTERS; ESCHERICHIA-COLI; CRYSTAL-STRUCTURE; STRANDED-DNA; RADIATION-RESISTANCE; POSTIRRADIATION RECOVERY; MICROCOCCUS-RADIODURANS; THERMUS-THERMOPHILUS;

D O I：

10.1134/S0006297915100016

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The bacterium Deinococcus radiodurans reveals extraordinary resistance to ionizing radiation, oxidative stress, desiccation, and other damaging conditions. In this review, we consider the main molecular mechanisms underlying such resistance, including the action of specific DNA repair and antioxidation systems, and transcription regulation during the anti-stress response.

引用

页码：1201 / 1216

页数：16

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