NKG2D Expression on HIV-Specific CD8+ T cells Is Reduced in Viremic HIV-1-Infected Patients but Maintained in HIV Controllers

被引：3

作者：

Lecuroux, Camille ^{[1
]}

Saez-Cirion, Asier ^{[2
]}

Noel, Nicolas ^{[1
]}

Ben-Lamine, Lilia ^{[1
]}

Girault, Isabelle ^{[1
]}

Caillat-Zucman, Sophie ^{[3
]}

Scott-Algara, Daniel ^{[2
]}

Venet, Alain ^{[1
]}

Lambotte, Olivier ^{[1
,4
,5
]}

机构：

[1] INSERM, U1012, F-94275 Le Kremlin Bicetre, France

[2] Inst Pasteur, Unite Regulat Infect Retrovirales, Paris, France

[3] Hop St Vincent de Paul, INSERM, U986, F-75674 Paris, France

[4] Univ Paris 11, U1012, Le Kremlin Bicetre, France

[5] Hop Bicetre, AP HP, Serv Med Interne & Malad Infect, Le Kremlin Bicetre, France

来源：

JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES | 2013年 / 62卷 / 01期

关键词：

NKG2D; HIV-specific CD8(+) T lymphocytes; inflammation; HIV controllers; NATURAL-KILLER-CELLS; ACTIVATION; INFECTION; RECEPTOR; LIGANDS; IMMUNORECEPTOR; LYMPHOCYTES; ABSENCE; RNA;

D O I：

10.1097/QAI.0b013e318274579f

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

NKG2D mediates an important costimulatory pathway in CD8(+) T cells. In HIV infection, the authors found that NKG2D expression on both total CD8(+) and HIV-specific CD8(+) T cells was significantly lower in viremic patients than in HIV controllers. Antiretroviral therapy partially restored NKG2D expression on HIV-specific CD8(+) T cells. The authors observed a negative correlation between the respective expression levels of CD38 and NKG2D on total CD8(+) and HIV-specific CD8(+) T cells. The maintenance of NKG2D expression on CD8(+) T cells in HIV controllers may contribute to better cell function.

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页码：17 / 20

页数：4

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