Apoptosis in the aging liver

被引：27

作者：

Zhong, Hua-Hua ^{[1
]}

Hu, Shao-Jie ^{[1
]}

Yu, Bo ^{[1
]}

Jiang, Sha-Sha ^{[1
]}

Zhang, Jin ^{[1
]}

Luo, Dan ^{[1
]}

Yang, Mei-Wen ^{[1
]}

Su, Wan-Ying ^{[1
]}

Shao, Ya-Lan ^{[1
]}

Deng, Hao-Lin ^{[1
]}

Hong, Fen-Fang ^{[2
]}

Yang, Shu-Long ^{[1
]}

机构：

[1] Nanchang Univ, Coll Med, Dept Physiol, Nanchang 330006, Jiangxi, Peoples R China

[2] Nanchang Univ, Dept Expt Teaching Ctr, Nanchang 330031, Jiangxi, Peoples R China

来源：

ONCOTARGET | 2017年 / 8卷 / 60期

基金：

中国国家自然科学基金;

关键词：

apoptosis; aging; liver; oxidative stress; genomic instability; ENDOPLASMIC-RETICULUM STRESS; MITOCHONDRIAL-DNA MUTATIONS; OXIDATIVE STRESS; MOLECULAR-MECHANISMS; CALORIE RESTRICTION; CASPASE ACTIVATION; CELL COMPETITION; SENESCENT CELLS; KAPPA-B; TELOMERE;

D O I：

10.18632/oncotarget.21123

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Various changes in the liver during aging can reduce hepatic function and promote liver injury. Aging is associated with high morbidity and a poor prognosis in patients with various liver diseases, including nonalcoholic fatty liver disease, hepatitis C and liver cancer, as well as with surgeries such as partial hepatectomy and liver transplantation. In addition, apoptosis increases with liver aging. Because apoptosis is involved in regeneration, fibrosis and cancer prevention during liver aging, and restoration of the appropriate level of apoptosis can alleviate the adverse effects of liver aging, it is important to understand the mechanisms underlying this process. Herein, we elaborate on the causes of apoptosis during liver aging, with a focus on oxidative stress, genomic instability, lipotoxicity, endoplasmic reticulum stress, dysregulation of nutrient sensing, and liver stem/progenitor cell activity.

引用

页码：102640 / 102652

页数：13

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