Relationship between resolution of non-alcoholic steatohepatitis and changes in lipoprotein sub-fractions: a post-hoc analysis of the PIVENS trial

被引：23

作者：

Corey, Kathleen E. ^{[1
]}

Wilson, Laura A. ^{[2
]}

Altinbas, Akif ^{[1
]}

Yates, Katherine P. ^{[2
]}

Kleiner, David E. ^{[3
,16
]}

Chung, Raymond T. ^{[1
]}

Krauss, Ronald M. ^{[4
]}

Chalasani, Naga ^{[5
]}

Bringman, Diane ^{[6
]}

Dasarathy, Srinivasan ^{[6
]}

Feldstein, Ariel ^{[6
]}

Hawkins, Carol ^{[6
]}

Liu, Yao-Chang ^{[6
]}

McCullough, Arthur ^{[6
]}

Sargent, Ruth ^{[6
]}

Stager, Margaret ^{[6
]}

Abdelmalek, Manal ^{[7
]}

Diehl, Anna Mae ^{[7
]}

Gottfried, Marcia ^{[7
]}

Guy, Cynthia ^{[7
]}

Killenberg, Paul ^{[7
]}

Kwan, Samantha ^{[7
]}

Pan, Yi-Ping ^{[7
]}

Piercy, Dawn ^{[7
]}

Smith, Melissa ^{[7
]}

Pfeifer, Kimberly ^{[8
]}

Scheimann, Ann O. ^{[8
]}

Torbenson, Michael ^{[8
]}

Bhimalli, Prajakta ^{[5
]}

Byam, Elizabeth ^{[5
]}

Chalasani, Naga ^{[5
]}

Cummings, Oscar W. ^{[5
]}

Klipsch, Ann ^{[5
]}

Lee, Lydia ^{[5
]}

Molleston, Jean P. ^{[5
]}

Ragozzino, Linda ^{[5
]}

Subbarao, Girish ^{[5
]}

Vuppalanchi, Raj ^{[5
]}

Barlow, Sarah ^{[9
]}

Brunt, Elizabeth M. ^{[9
]}

Derdoy, Jose ^{[9
]}

Hoffmann, Joyce ^{[9
]}

King, Debra ^{[9
]}

Siegner, Joan ^{[9
]}

Stewart, Susan ^{[9
]}

Neuschwander-Tetri, Brent A. ^{[9
]}

Thompson, Judy ^{[9
]}

Abrams, Stephanie H. ^{[10
]}

Arceo, Diana ^{[10
]}

Espinosa, Denise ^{[10
]}

机构：

[1] Harvard Med Sch, Massachusetts Gen Hosp, Boston, MA 02115 USA

[2] Johns Hopkins Bloomberg Sch Publ Hlth, Baltimore, MD USA

[3] NCI, Pathol Lab, NIH, Bldg 10, Bethesda, MD 20892 USA

[4] Childrens Hosp Oakland, Res Inst, Oakland, CA 94609 USA

[5] Indiana Univ Sch Med, Indianapolis, IN 46202 USA

[6] Case Western Reserve Univ, Cleveland, OH 44106 USA

[7] Duke Univ, Med Ctr, Durham, NC USA

[8] Johns Hopkins Univ, Sch Med, Baltimore, MD USA

[9] St Louis Univ, Sch Med, St Louis, MO USA

[10] Baylor Coll Med, Houston, TX 77030 USA

[11] Univ Calif San Diego, San Diego, CA 92103 USA

[12] Univ Calif San Francisco, San Francisco, CA 94143 USA

[13] Univ Washington, Med Ctr, Virginia Mason Med Ctr, Seattle, WA 98195 USA

[14] Virginia Commonwealth Univ, Richmond, VA USA

[15] Childrens Natl Med Ctr, Washington, DC 20010 USA

[16] NCI, Bethesda, MD 20892 USA

[17] NIDDK, Bethesda, MD 20892 USA

[18] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Bethesda, MD USA

[19] Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Data Coordinating Ctr, Baltimore, MD USA

来源：

ALIMENTARY PHARMACOLOGY & THERAPEUTICS | 2019年 / 49卷 / 09期

关键词：

FATTY LIVER-DISEASE; LOW-DENSITY-LIPOPROTEIN; MAGNETIC-RESONANCE SPECTROSCOPY; CORONARY-HEART-DISEASE; CARDIOVASCULAR-DISEASE; ION MOBILITY; E-SELECTIN; RISK; ATHEROSCLEROSIS; DYSLIPIDEMIA;

D O I：

10.1111/apt.15216

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Background Dyslipidaemia is frequent in non-alcoholic steatohepatitis (NASH); however, it is unclear if improvement in liver histology is associated with favourable changes in cardiovascular disease (CVD) risk. Aims To evaluate the relationship of NASH resolution and lipoprotein subfraction levels, markers of endothelial dysfunction, and macrophage activation. Methods One hundred and seventeen individuals with NASH who participated in the Pioglitazone vs Vitamin E vs Placebo for the Treatment of Nondiabetic Patients with NASH (PIVENS) trial with paired liver biopsies and serum samples available at baseline and after 96 weeks of treatment were included. Participants in the PIVENS trials received vitamin E, pioglitazone, or placebo for 96 weeks. Lipoprotein subfraction levels, intracellular adhesion molecule 1 (ICAM-1), vascular cellular adhesion molecule 1 (VCAM-1), E-selectin, and sCD163 levels were assessed at baseline and week 96 and their relationship with NASH resolution was examined. Results Fifty-seven individuals had NASH resolution and 60 individuals did not have resolution of NASH. NASH resolution was associated with favourable changes in lipoprotein subfraction levels compared to those without NASH resolution. Individuals with resolution of NASH had a significantly increased mean peak LDL diameter (ratio of geometric means [96 weeks vs baseline] 1.007 vs 0.996, P = 0.004), and higher frequency of LDL phenotype A (58% vs 33%, P = 0.003) at week 96, after adjustment for relevant co-variates including treatment group. No differences in VCAM, ICAM, E-selectin, or sCD163 levels by NASH resolution were found. Conclusions NASH resolution is associated with favourable changes in a subset of serum lipoprotein levels. More studies are warranted to understand if these favourable changes are associated with decreased risk of CVD.

引用

页码：1205 / 1213

页数：9

共 31 条

[1] The natural history of nonalcoholic fatty liver disease: A population-based cohort study
Adams, LA
Lymp, JF
St Sauver, J
Sanderson, SO
Lindor, KD
Feldstein, A
Angulo, P
[J]. GASTROENTEROLOGY, 2005, 129 (01) : 113 - 121
[2] Overproduction of large VLDL particles is driven by increased liver fat content in man
Adiels, M
Taskinen, MR
Packard, C
Caslake, MJ
Soro-Paavonen, A
Westerbacka, J
Vehkavaara, S
Hakkinen, A
Olofsson, SO
Yki-Jarvinen, H
Borén, J
[J]. DIABETOLOGIA, 2006, 49 (04) : 755 - 765
[3] The monocytic lineage specific soluble CD163 is a plasma marker of coronary atherosclerosis
Aristoteli, LP
Moller, HJ
Bailey, B
Moestrup, SK
Kritharides, L
[J]. ATHEROSCLEROSIS, 2006, 184 (02) : 342 - 347
[4] AUSTIN MA, 1988, JAMA-J AM MED ASSOC, V260, P1917
[5] Low-density lipoprotein particle concentration and size as determined by nuclear magnetic resonance spectroscopy as predictors of cardiovascular disease in women
Blake, GJ
Otvos, JD
Rifai, N
Ridker, PM
[J]. CIRCULATION, 2002, 106 (15) : 1930 - 1937
[6] Direct determination of lipoprotein particle sizes and concentrations by ion mobility analysis
Caulfield, Michael P.
Li, Shuguang
Lee, Gloria
Blanche, Patricia J.
Salarneh, Wael A.
Benner, W. Henry
Reitz, Richard E.
Krauss, Ronald M.
[J]. CLINICAL CHEMISTRY, 2008, 54 (08) : 1307 - 1316
[7] NASH resolution is associated with improvements in HDL and triglyceride levels but not improvement in LDL or non-HDL-C levels
Corey, K. E.
Vuppalanchi, R.
Wilson, L. A.
Cummings, O. W.
Chalasani, N.
[J]. ALIMENTARY PHARMACOLOGY & THERAPEUTICS, 2015, 41 (03) : 301 - 309
[8] Improvement in Liver Histology Is Associated With Reduction in Dyslipidemia in Children With Nonalcoholic Fatty Liver Disease
Corey, Kathleen E.
Vuppalanchi, Raj
Vos, Miriam
Kohli, Rohit
Molleston, Jean P.
Wilson, Laura
Unalp-Arida, Aynur
Cummings, Oscar W.
Lavine, Joel E.
Chalasani, Naga
[J]. JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION, 2015, 60 (03) : 360 - 367
[9] Nonalcoholic steatohepatitis is associated with an atherogenic lipoprotein subfraction profile
Corey, Kathleen E.
Misdraji, Joseph
Gelrud, Lou
Zheng, Hui
Chung, Raymond T.
Krauss, Ronald M.
[J]. LIPIDS IN HEALTH AND DISEASE, 2014, 13
[10] Non-High-Density Lipoprotein Cholesterol as a Biomarker for Nonalcoholic Steatohepatitis
Corey, Kathleen E.
Lai, Michelle
Gelrud, Louis G.
Misdraji, Joseph
Barlow, Lydia L.
Zheng, Hui
Andersson, Karin L.
Thiim, Michael
Pratt, Daniel S.
Chung, Raymond T.
[J]. CLINICAL GASTROENTEROLOGY AND HEPATOLOGY, 2012, 10 (06) : 651 - 656

← 1 2 3 4 →