Emergence of OXA-232 Carbapenemase-Producing Klebsiella pneumoniae That Carries a pLVPK-Like Virulence Plasmid among Elderly Patients in China

被引：70

作者：

Shu, Lingbin ^{[1
]}

Dong, Ning ^{[2
,3
]}

Lu, Jun ^{[4
]}

Zheng, Zhiwei ^{[2
,3
]}

Hu, Jie ^{[1
]}

Zeng, Wenqing ^{[4
]}

Sun, Qiaoling ^{[1
]}

Chan, Edward Wai-Chi ^{[2
,3
]}

Zhou, Hongwei ^{[1
]}

Hu, Fupin ^{[5
,6
]}

Chen, Sheng ^{[2
,3
]}

Zhang, Rong ^{[1
]}

机构：

[1] Zhejiang Univ, Sch Med, Affiliated Hosp 2, Dept Clin Lab Med, Hangzhou, Zhejiang, Peoples R China

[2] Hong Kong PolyU Shen Zhen Res Inst, Food Safety & Technol Res Ctr, Shenzhen Key Lab Food Biol Safety Control, Shenzhen, Peoples R China

[3] Hong Kong Polytech Univ, Dept Appl Biol & Chem Technol, State Key Lab Chirosci, Hung Hom,Kowloon, Hong Kong, Peoples R China

[4] Zhejiang Chinese Med Univ, Affiliated Hosp 2, Hangzhou, Zhejiang, Peoples R China

[5] Fudan Univ, Huashan Hosp, Inst Antibiot, Shanghai, Peoples R China

[6] Minist Hlth, Key Lab Clin Pharmacol Antibiot, Shanghai, Peoples R China

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2019年 / 63卷 / 03期

基金：

中国国家自然科学基金;

关键词：

Klebsiella pneumoniae; OXA-232; clonal spread; virulence plasmid; virulence potential; D BETA-LACTAMASE;

D O I：

10.1128/AAC.02246-18

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

This study reported the clonal dissemination of OXA-232-producing sequence type 15 (ST15) carbapenem-resistant Klebsiella pneumoniae among elderly patients in China. All patients were immunocompromised, suffered from multiple underlying diseases, and were hospitalized for a prolonged period; however, they slowly recovered on antimicrobial therapy. The blaOXA-232 gene was in a 6.1-kb ColKP3-type nonconjugative plasmid. The strains displayed a multidrug resistance phenotype and were not hypervirulent despite harboring a virulence plasmid. Active surveillance should be enforced to control further transmission.

引用

页数：6

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