Manganese(I)-Catalyzed C-H (2-Indolyl)methylation: Expedient Access to Diheteroarylmethanes

被引：83

作者：

Lu, Qingquan ^{[1
]}

Cembellin, Sara ^{[1
]}

Gressies, Steffen ^{[1
]}

Singha, Santanu ^{[1
]}

Daniliuc, Constantin G. ^{[1
]}

Glorius, Frank ^{[1
]}

机构：

[1] Westfal Wilhelms Univ Munster, Organ Chem Inst, Corrensstr 40, D-48149 Munster, Germany

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2018年 / 57卷 / 05期

关键词：

C-H activation; diheteroarylmethane derivatives; ethynyl benzoxazinanone; (2-indolyl)methylation; manganese; MANGANESE-CATALYZED SYNTHESIS; BOND FORMATION; ROBUSTNESS SCREEN; CASCADE REACTION; 4+2 ANNULATION; ACTIVATION; FUNCTIONALIZATION; HETEROARYLATION; ESTERS; IMINES;

D O I：

10.1002/anie.201710060

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An unprecedented Mn-I-catalyzed (2-indolyl)methylation of heteroarenes is reported. This method makes use of an aromatizing cascade strategy to install a (2-indolyl)methyl group into target molecules, thereby leading to the expedient synthesis of previously challenging and important unsymmetrical diheteroarylmethanes, in particular bis(2-indolyl)methanes. The proposed cascade process comprises the reorganization of multiple bonds with controlled regioselectivity and high atom economy and can be performed on a gram-scale. Furthermore, a metal-free C-H propargylation is observed. The diverse application of this method is also demonstrated.

引用

页码：1399 / 1403

页数：5

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