Synthesis and antimicrobial activity of derivatives of 1H-benzo[de]isoquinoline-1,3(2H)-dione

被引：3

作者：

Kuran, Bozena ^{[1
]}

Krawiecka, Mariola ^{[1
]}

Kossakowski, Jerzy ^{[1
]}

Szymanek, Ksenia ^{[2
]}

Kierzkowska, Marta ^{[2
]}

Mlynarczyk, Grazyna ^{[2
]}

机构：

[1] Med Univ Warsaw, Dept Med Chem, PL-02007 Warsaw, Poland

[2] Med Univ Warsaw, Dept Med Microbiol, PL-02004 Warsaw, Poland

来源：

HETEROCYCLIC COMMUNICATIONS | 2012年 / 18卷 / 5-6期

关键词：

antifungal activity; antimicrobial activity; 1H-benzo[de]isoquinoline-1,3(2H)-dione; ANTINEOPLASTIC AGENTS; ANTITUMOR-ACTIVITY; DNA; ANALOGS; METRONIDAZOLE; INHIBITION; AMONAFIDE; ACID;

D O I：

10.1515/hc-2012-0115

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Five aminoalkyl 1H-benzo[de]isoquinoline-1,3(2H)-diones were synthesized and evaluated for antimicrobial activity. Microorganisms used in this study included aerobic and facultative anaerobic bacteria Staphylococcus aureus, Escherichia coli and Stenotrophomonas maltophilia, and obligatory anaerobes Bacteroides fragilis, Bacteroides thetaiotaomicron and Propionibacterium acnes. Moreover, Candida albicans yeast was used. The minimum inhibitory concentration (MIC) was determined for the test compounds. Among the tested derivatives, two compounds 1 and 2 have shown the most potent antibacterial as well as antifungal activities.

引用

页码：275 / 278

页数：4

共 37 条

[11]

Huang S., 2009, Patent, Patent No. [WO2009/89537 A2, 200989537]

[12] ANTIMICROBIAL ACTIVITIES OF SOME N-ALKYLMALEIMIDES [J].

IGARASHI, Y ;

YAGAMI, K ;

IMAI, R ;

WATANABE, S .

JOURNAL OF INDUSTRIAL MICROBIOLOGY, 1990, 6 (03) :223-225

[13] NEW ANTIBIOTIC, ISOHEMATINIC ACID .2. PHYSICOCHEMICAL PROPERTIES, STRUCTURAL ELUCIDATION AND BIOLOGICAL-ACTIVITIES [J].

ITOH, Y ;

TAKEUCHI, M ;

SHIMIZU, K ;

TAKAHASHI, S ;

TERAHARA, A ;

HANEISHI, T .

JOURNAL OF ANTIBIOTICS, 1983, 36 (05) :497-501

[14]

Kazantsev A., 2005, Patent, Patent No. [WO2005/87217 A1, 200587217]

[15]

Kuran B., 2010, ANN DDD 23, V4, P19

[16]

Kuran B, 2012, ACTA POL PHARM, V69, P901

[17] The cephalosporins [J].

Marshall, WF ;

Blair, JE .

MAYO CLINIC PROCEEDINGS, 1999, 74 (02) :187-195

[18] LOCAL ANESTHETICS - N-DIALKYLAMINOALKYLIMIDES OF NAPHTHALIC AND DIPHENYLMALEIC ACIDS [J].

MATTOCKS, AM ;

HUTCHISON, OS .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1948, 70 (10) :3474-3475

[19] Antitumor efficacy and apoptotic activity of substituted chloroalkyl 1H-benz[de]isoquinoline-1,3-diones: a new class of potential antineoplastic agents [J].

Mukherjee, Asama ;

Hazra, Suva ;

Dutta, Sushanta ;

Muthiah, Shanmugavel ;

Mondhe, Dilip Manikrao ;

Sharma, Parduman Raj ;

Singh, Shashank Kumar ;

Saxena, Ajit Kumar ;

Qazi, Gulam Nabi ;

Sanyal, Utpal .

INVESTIGATIONAL NEW DRUGS, 2011, 29 (03) :434-442

[20] Systematic development of high affinity bis(ammonio)alkane-type allosteric enhancers of muscarinic ligand binding [J].

Muth, M ;

Bender, W ;

Scharfenstein, O ;

Holzgrabe, U ;

Balatkova, E ;

Tränkle, C ;

Mohr, K .

JOURNAL OF MEDICINAL CHEMISTRY, 2003, 46 (06) :1031-1040

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