Prognostic value of trisomy 8 as a single anomaly and the influence of additional cytogenetic aberrations in primary myelodysplastic syndromes

被引：27

作者：

Saumell, Silvia ^{[1
,2
]}

Florensa, Lourdes ^{[1
]}

Luno, Elisa ^{[3
]}

Sanzo, Carmen ^{[3
]}

Canizo, Consuelo ^{[4
]}

Hernandez, Jesus M. ^{[4
]}

Cervera, Jose ^{[5
]}

Gallart, Miguel A. ^{[6
]}

Carbonell, Felix ^{[7
]}

Collado, Rosa ^{[7
]}

Arenillas, Leonor ^{[1
]}

Pedro, Carme ^{[1
]}

Bargay, Joan ^{[8
]}

Nomdedeu, Benet ^{[9
]}

Xicoy, Blanca ^{[10
]}

Vallespi, Teresa ^{[11
]}

Raya, Jose M. ^{[12
]}

Belloch, Luis ^{[5
]}

Sanz, Guillermo F. ^{[5
]}

Sole, Francesc ^{[1
]}

机构：

[1] Hosp del Mar, Lab Citogenet Mol, Lab Citol Hematol, Serv Patol & Hematol Clin,GRETHNE,IMIM,Res Inst, Barcelona 08003, Spain

[2] Univ Autonoma Barcelona, Dept Med, Fac Med, Bellaterra, Spain

[3] Hosp Univ Cent Asturias, Serv Hematol, Oviedo, Spain

[4] Hosp Univ Salamanca, Serv Hematol, Salamanca, Spain

[5] Hosp Univ La Fe, Serv Hematol, Valencia, Spain

[6] Hosp Arnau Vilanova, Serv Hematol, Lleida, Spain

[7] Hosp Gen Valencia, Serv Hematol, Valencia, Spain

[8] Hosp Son Llatzer, Serv Hematol, Mallorca, Spain

[9] Hosp Clin Barcelona, Serv Hematol, Barcelona, Spain

[10] Hosp Badalona Germans Trias & Pujol, Serv Hematol, Badalona, Spain

[11] Hosp Valle De Hebron, Serv Hematol, Barcelona, Spain

[12] Hosp Univ Canarias, Serv Hematol, San Cristobal la Laguna, Spain

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 2012年 / 159卷 / 03期

关键词：

trisomy; 8; myelodysplastic syndromes; cytogenetic aberrations; SOLE CHROMOSOMAL-ABERRATION; ACUTE MYELOID-LEUKEMIA; SCORING SYSTEM; ABNORMALITIES; MDS; KARYOTYPE; IMPACT;

D O I：

10.1111/bjh.12035

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Trisomy 8 is the most common chromosomal gain in myelodysplastic syndromes (MDS), however, little is known about the features of MDS with isolated trisomy 8 and the influence of additional cytogenetic aberrations. We determined the characteristics and prognostic factors of 72 patients with trisomy 8 as a single anomaly and analysed also the impact of other aberrations added to trisomy 8 in another 62 patients. According to our study, MDS with isolated trisomy 8 was more frequent in men, with more than one cytopenia in most patients (62%) and having about 4% bone marrow blasts. The multivariate analysis demonstrated that platelet count and percentage bone marrow blasts had the strongest impact on overall survival (OS). The median OS for isolated trisomy 8, trisomy 8 plus one aberration (tr8+1), plus two (tr8+2) and plus three or more aberrations (tr8 >= 3) was 34.3, 40, 23.4 and 5.8months, respectively (P<0.001). Trisomy 8 confers a poorer prognosis than a normal karyotype in MDS patients with >= 5% bone marrow blasts. This study supports the view that MDS with isolated trisomy 8 should be included in the intermediate cytogenetic risk group.

引用

页码：311 / 321

页数：11

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