Highly enantioselective Friedel-Crafts alkylation of indoles and pyrrole with β,γ-unsaturated α-ketoesters catalyzed by heteroarylidene-tethered bis(oxazoline) copper complexes

被引：58

作者：

Liu, Lei ^{[1
]}

Ma, Hongli ^{[1
]}

Xiao, Yumei ^{[1
]}

Du, Fengpei ^{[1
]}

Qin, Zhaohai ^{[1
]}

Li, Nan ^{[1
]}

Fu, Bin ^{[1
]}

机构：

[1] China Agr Univ, Dept Appl Chem, Beijing 100193, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2012年 / 48卷 / 74期

基金：

中国国家自然科学基金;

关键词：

LIGAND BITE-ANGLE; PHOSPHORIC-ACIDS;

D O I：

10.1039/c2cc34803a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The simple and cheap chiral catalyst, heteroarylidene-tethered Ph-bis(oxazoline)-Cu(OTf)(2), can efficiently catalyze the asymmetric F-C alkylation of indoles and pyrrole with beta,gamma-unsaturated alpha-ketoesters. The 3-indolyl adducts were obtained in up to > 99% ee. Moreover, the 2-pyrrolyl adducts were achieved in up to 92% ee for the first time.

引用

页码：9281 / 9283

页数：3

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