Genetic Basis of Pancreas Cancer Development and Progression: Insights from Whole-Exome and Whole-Genome Sequencing

被引：112

作者：

Iacobuzio-Donahue, Christine A. ^{[1
,2
,3
]}

Velculescu, Victor E. ^{[2
]}

Wolfgang, Christopher L. ^{[2
,3
]}

Hruban, Ralph H. ^{[1
,2
]}

机构：

[1] Johns Hopkins Univ, Sch Med, Sol Goldman Pancreat Canc Res Ctr, Dept Pathol, Baltimore, MD 21231 USA

[2] Johns Hopkins Univ, Sch Med, Sol Goldman Pancreat Canc Res Ctr, Dept Oncol, Baltimore, MD 21231 USA

[3] Johns Hopkins Univ, Sch Med, Sol Goldman Pancreat Canc Res Ctr, Dept Surg, Baltimore, MD 21231 USA

来源：

CLINICAL CANCER RESEARCH | 2012年 / 18卷 / 16期

基金：

美国国家卫生研究院;

关键词：

PAPILLARY MUCINOUS NEOPLASMS; ACINAR CELL-CARCINOMA; INTRAEPITHELIAL NEOPLASIA; POLY(ADP-RIBOSE) POLYMERASE; HOMOLOGOUS RECOMBINATION; NEUROENDOCRINE TUMORS; DUCTAL ADENOCARCINOMA; MUTATIONS; BRCA2; RISKS;

D O I：

10.1158/1078-0432.CCR-12-0315

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Pancreatic cancer is caused by inherited and acquired mutations in specific cancer-associated genes. The discovery of the most common genetic alterations in pancreatic cancer has provided insight into the fundamental pathways that drive the progression from a normal cell to noninvasive precursor lesions and finally to widely metastatic disease. In addition, recent genetic discoveries have created new opportunities to develop gene-based approaches for early detection, personalized treatment, and molecular classification of pancreatic neoplasms. Clin Cancer Res; 18(16); 4257-65. (C) 2012 AACR.

引用

页码：4257 / 4265

页数：9

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