Nucleosome formation potential of exons, introns, and Alu repeats

被引：19

作者：

Levitsky, VG ^{[1
]}

Podkolodnaya, OA ^{[1
]}

Kolchanov, NA ^{[1
]}

Podkolodny, NL ^{[1
]}

机构：

[1] Inst Cytol & Genet, Lab Theoret Genet, Novosibirsk 630090, Russia

来源：

BIOINFORMATICS | 2001年 / 17卷 / 11期

基金：

俄罗斯基础研究基金会;

关键词：

D O I：

10.1093/bioinformatics/17.11.1062

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

A program for constructing nucleosome formation potential profile was applied for investigation of exons, introns, and repetitive sequences. The program is available at http: //wwwmgs.bionet.nsc.ru/mgs/programs/recon/. We have demonstrated that introns and repetitive sequences exhibit higher nucleosome formation potentials than exons. This fact may be explained by functional saturation of exons with genetic code, hindering the localization of efficient nucleosome positioning sites.

引用

页码：1062 / 1064

页数：3

共 13 条

[1] TGGA repeats impair nucleosome formation [J].

Cao, H ;

Widlund, HR ;

Simonsson, T ;

Kubista, M .

JOURNAL OF MOLECULAR BIOLOGY, 1998, 281 (02) :253-260

[2] A PROPOSAL FOR A POSSIBLE ROLE OF NUCLEOSOME POSITIONING IN THE EVOLUTIONARY ADJUSTMENT OF INTRONS [J].

CSORDAS, A .

INTERNATIONAL JOURNAL OF BIOCHEMISTRY, 1989, 21 (05) :455-461

[3] Protective nucleosome centering at splice sites as suggested by sequence-directed mapping of the nucleosomes [J].

Denisov, DA ;

Shpigelman, ES ;

Trifonov, EN .

GENE, 1997, 205 (1-2) :145-149

[4] NUCLEOSOME POSITIONING BY HUMAN ALU ELEMENTS IN CHROMATIN [J].

ENGLANDER, EW ;

HOWARD, BH .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (17) :10091-10096

[5]

FITZGERALD DJ, 1994, J BIOL CHEM, V269, P21303

[6] INTRONS OF THE CHICKEN OVALBUMIN GENE PROMOTE NUCLEOSOME ALIGNMENT INVITRO [J].

LAUDERDALE, JD ;

STEIN, A .

NUCLEIC ACIDS RESEARCH, 1992, 20 (24) :6589-6596

[7] Nucleosomal DNA property database [J].

Levitsky, VG ;

Ponomarenko, MP ;

Ponomarenko, JV ;

Frolov, AS ;

Kolchanov, NA .

BIOINFORMATICS, 1999, 15 (7-8) :582-592

[8]

LEVITSKY VG, 2001, BIOINFORMATICS

[9] RAT GROWTH-HORMONE GENE INTRONS STIMULATE NUCLEOSOME ALIGNMENT IN-VITRO AND IN TRANSGENIC MICE [J].

LIU, K ;

SANDGREN, EP ;

PALMITER, RD ;

STEIN, A .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (17) :7724-7728

[10] DNA sequence encodes information for nucleosome array formation [J].

Liu, K ;

Stein, A .

JOURNAL OF MOLECULAR BIOLOGY, 1997, 270 (04) :559-573

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