Involvement of the Novel Two-Component NsrRS and LcrRS Systems in Distinct Resistance Pathways against Nisin A and Nukacin ISK-1 in Streptococcus mutans

被引：29
作者：
Kawada-Matsuo, Miki [1 ]
Oogai, Yuichi [1 ]
Zendo, Takeshi [2 ]
Nagao, Junichi [3 ]
Shibata, Yukie [4 ]
Yamashita, Yoshihisa [4 ]
Ogura, Yoshitoshi [5 ]
Hayashi, Tetsuya [5 ]
Sonomoto, Kenji [2 ]
Komatsuzawa, Hitoshi [1 ]
机构：
[1] Kagoshima Univ, Dept Oral Microbiol, Grad Sch Med & Dent Sci, Kagoshima 890, Japan
[2] Kyushu Univ, Fac Agr, Dept Biosci & Biotechnol, Grad Sch, Fukuoka 812, Japan
[3] Fukuoka Dent Coll, Dept Funct Biosci, Sect Infect Biol, Fukuoka, Japan
[4] Kyushu Univ, Sect Prevent & Publ Hlth Dent, Div Oral Hlth Growth & Dev, Fac Dent Sci, Fukuoka 812, Japan
[5] Miyazaki Univ, Div Microbiol, Dept Infect Dis, Fac Med, Miyazaki, Japan
来源：
APPLIED AND ENVIRONMENTAL MICROBIOLOGY | 2013年 / 79卷 / 15期
关键词：
STAPHYLOCOCCUS-WARNERI ISK-1; GROUP-I STRAIN; ANTIMICROBIAL PEPTIDES; BACILLUS-SUBTILIS; MUTACIN-I; GENES; BACTERIOCIN; BACITRACIN; IMMUNITY; IDENTIFICATION;
D O I：
10.1128/AEM.00780-13
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
The novel two-component systems NsrRS and LcrRS are individually associated with resistance against the distinct lantibiotics nisin A and nukacin ISK-1 in Streptococcus mutans. NsrRS regulates the expression of NsrX, which is associated with nisin A binding, and LcrRS regulates the expression of the ABC transporter LctFEG.
引用
收藏
页码：4751 / 4755
页数：5
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