The effect of anti-angiogenic drugs on regulatory T cells in the tumor microenvironment

被引：23

作者：

Hu, Chenxi ^{[1
]}

Jiang, Xiaodong ^{[1
]}

机构：

[1] Xuzhou Med Univ, Dept Oncol, Tumor Lab, Affiliated Lianyungang Hosp, 182 Tongguan Rd, Lianyungang 222002, Jiangsu, Peoples R China

来源：

BIOMEDICINE & PHARMACOTHERAPY | 2017年 / 88卷

基金：

中国国家自然科学基金;

关键词：

Anti-angiogenics; Tumor microenvironment; Regulatory T cells; DENDRITIC CELLS; ANTIANGIOGENIC THERAPY; DIFFERENTIAL ROLES; VEGF THERAPY; CANCER; GROWTH; SUPPRESSION; RECRUITMENT; SURVIVAL; INFILTRATION;

D O I：

10.1016/j.biopha.2017.01.051

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

A benefit of anti-angiogenic drugs is improved tumor immune tolerance. Regulatory T cells (Tregs) in the tumor microenvironment mediate tumor immune tolerance and anti-angiogenic drugs not only indirectly affect Tregs via dendritic cells (DCs) and myeloid-derived suppressor cells (MDSCs) but they can also act directly on Tregs causing immunosuppression. Specifically, these drugs may induce differentiation and chemotaxis and reduce the number and function of Tregs by targeting vascular endothelial growth factor receptor 2 (VEGFR-2) and neuropilin-1 (NRP-1) on the cell surface. Recently, anti-angiogenic drugs have been documented to promote a new way of thinking about tumor immunotherapy: clinical application of Tregs and related immunosuppressive molecules may be promising targets for synergistic tumor immunotherapy. (C) 2017 Elsevier Masson SAS. All rights reserved.

引用

页码：134 / 137

页数：4

共 58 条

[1] Involvement of IFN-γ and perforin, but not Fas/FasL interactions in regulatory T cell-mediated suppression of experimental autoimmune encephalomyelitis [J].

Beeston, Tara ;

Smith, Trevor R. F. ;

Maricic, Igor ;

Tang, Xiaolei ;

Kumar, Vipin .

JOURNAL OF NEUROIMMUNOLOGY, 2010, 229 (1-2) :91-97

[2] Defective blood dendritic cells in chronic myeloid leukemia correlate with high plasmatic VEGF and are not normalized by imatinib mesylate [J].

Boissel, N ;

Rousselot, P ;

Raffoux, E ;

Cayuela, JM ;

Maarek, O ;

Charron, D ;

Degos, L ;

Dombret, H ;

Toubert, A ;

Rea, D .

LEUKEMIA, 2004, 18 (10) :1656-1661

[3] Neuropilin-1: a surface marker of regulatory T cells [J].

Bruder, D ;

Probst-Kepper, M ;

Westendorf, AM ;

Geffers, R ;

Beissert, S ;

Loser, K ;

von Boehmer, H ;

Buer, J ;

Hansen, W .

EUROPEAN JOURNAL OF IMMUNOLOGY, 2004, 34 (03) :623-630

[4]

Bruno A, 2014, CANCER TREAT RES, V159, P401, DOI 10.1007/978-3-642-38007-5_23

[5] Immunosuppressive networks and checkpoints controlling antitumor immunity and their blockade in the development of cancer immunotherapeutics and vaccines [J].

Butt, A. Q. ;

Mills, K. H. G. .

ONCOGENE, 2014, 33 (38) :4623-4631

[6] Neuropilin 1: function and therapeutic potential in cancer [J].

Chaudhary, Belal ;

Khaled, Yazan S. ;

Ammori, Basil J. ;

Elkord, Eyad .

CANCER IMMUNOLOGY IMMUNOTHERAPY, 2014, 63 (02) :81-99

[7] Mesenchymal Stem Cell-Mediated Immature Dendritic Cells Induce Regulatory T Cell-Based Immunosuppressive Effect [J].

Choi, Yong-Soo ;

Jeong, Ju-Ah ;

Lim, Dae-Seog .

IMMUNOLOGICAL INVESTIGATIONS, 2012, 41 (02) :214-229

[8] Soluble factors secreted by glioblastoma cell lines facilitate recruitment, survival, and expansion of regulatory T cells: implications for immunotherapy [J].

Crane, Courtney A. ;

Ahn, Brian J. ;

Han, Seunggu J. ;

Parsa, Andrew T. .

NEURO-ONCOLOGY, 2012, 14 (05) :584-595

[9] Glycosylation-Dependent Lectin-Receptor Interactions Preserve Angiogenesis in Anti-VEGF Refractory Tumors [J].

Croci, Diego O. ;

Cerliani, Juan P. ;

Dalotto-Moreno, Tomas ;

Mendez-Huergo, Santiago P. ;

Mascanfroni, Ivan D. ;

Dergan-Dylon, Sebastian ;

Toscano, Marta A. ;

Caramelo, Julio J. ;

Garcia-Vallejo, Juan J. ;

Ouyang, Jing ;

Mesri, Enrique A. ;

Junttila, Melissa R. ;

Bais, Carlos ;

Shipp, Margaret A. ;

Salatino, Mariana ;

Rabinovich, Gabriel A. .

CELL, 2014, 156 (04) :744-758

[10] The Raf Kinase Inhibitor Sorafenib Inhibits JAK-STAT Signal Transduction in Human Immune Cells [J].

del Campo, Sara E. Martin ;

Levine, Kala M. ;

Mundy-Bosse, Bethany L. ;

Grignol, Valerie P. ;

Fairchild, Ene T. ;

Campbell, Amanda R. ;

Trikha, Prashant ;

Mace, Thomas A. ;

Paul, Bonnie K. ;

Jaime-Ramirez, Alena Cristina ;

Markowitz, Joseph ;

Kondadasula, Vidya ;

Guenterberg, Kristan D. ;

McClory, Susan ;

Karpa, Volodymyr I. ;

Pan, Xueliang ;

Olencki, Thomas E. ;

Monk, J. Paul ;

Mortazavi, Amir ;

Tridandapani, Susheela ;

Lesinski, Gregory B. ;

Byrd, John C. ;

Caligiuri, Michael A. ;

Shah, Manisha H. ;

Carson, William E., III .

JOURNAL OF IMMUNOLOGY, 2015, 195 (05) :1995-2005

← 1 2 3 4 5 6 →