Nanoporous Biodegradable Elastomers

被引：33

作者：

Hoshi, Ryan A. ^{[1
]}

Behl, Saloni ^{[1
]}

Ameer, Guillermo A. ^{[1
,2
,3
]}

机构：

[1] Northwestern Univ, Dept Biomed Engn, Evanston, IL 60208 USA

[2] Northwestern Univ, Feinberg Sch Med, Dept Surg, Chicago, IL 60611 USA

[3] Northwestern Univ, Inst BioNanotechnol Med, Chicago, IL 60611 USA

来源：

ADVANCED MATERIALS | 2009年 / 21卷 / 02期

关键词：

BIOACTIVE THERAPEUTIC PROTEINS; MECHANICAL-PROPERTIES; TISSUE; SCAFFOLDS; BIOCOMPATIBILITY; RELEASE;

D O I：

10.1002/adma.200801132

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A nanoporous biodegradable elastomer based on citric acid is described. Nanopores are used to control the mechanical and degradation properties of the elastomer. Furthermore, macromolecular drugs can be entrapped under mild conditions via pore collapse, which also delays the release of the drug. The nanoporous elastomer is biocompatible and a promising platform technology for engineering soft tissues.

引用

页码：188 / +

页数：6

共 25 条

[1] Characterization of porcine circulating progenitor cells: Toward a functional endothelium [J].

Allen, Josephine ;

Khan, Sadiya ;

Serrano, Maria Concepcion ;

Ameer, Guillermo .

TISSUE ENGINEERING PART A, 2008, 14 (01) :183-194

[2] Polyurethane films seeded with embryonic stem cell-derived cardiomyocytes for use in cardiac tissue engineering applications [J].

Alperin, C ;

Zandstra, PW ;

Woodhouse, KA .

BIOMATERIALS, 2005, 26 (35) :7377-7386

[3] Supercritical carbon dioxide foaming of elastomer/heterocyclic methacrylate blends as scaffolds for tissue engineering [J].

Barry, JJA ;

Nazhat, SN ;

Rose, FRAJ ;

Hainsworth, AH ;

Scotchford, CA ;

Howdle, SM .

JOURNAL OF MATERIALS CHEMISTRY, 2005, 15 (46) :4881-4888

[4]

Cadée JA, 2001, J BIOMED MATER RES, V56, P600, DOI 10.1002/1097-4636(20010915)56:4<600::AID-JBM1133>3.0.CO

[5]

2-I

[6] The influence of architecture on degradation and tissue ingrowth into three-dimensional poly(lactic-co-glycolic acid) scaffolds in vitro and in vivo [J].

Cao, Y ;

Mitchell, G ;

Messina, A ;

Price, L ;

Thompson, E ;

Penington, A ;

Morrison, W ;

O'Connor, A ;

Stevens, G ;

Cooper-White, J .

BIOMATERIALS, 2006, 27 (14) :2854-2864

[7] AN INVIVO MEASUREMENT AND ANALYSIS OF VISCOELASTIC PROPERTIES OF THE SPINAL-CORD OF CATS [J].

CHANG, GL ;

HUNG, TK ;

FENG, WW .

JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME, 1988, 110 (02) :115-122

[8] Multiporosity in dried poly(vinylidene fluoride)-camphor systems: Effect of drying method on porosity [J].

Dasgupta, Debarshi ;

Nandi, Arun K. .

MACROMOLECULES, 2007, 40 (06) :2008-2018

[9] Pore collapse during the fabrication process of rubber-like polymer scaffolds [J].

Diego, Raul Brigido ;

Gomez Ribelles, Jose Luis ;

Sanchez, Manuel Salmeron .

JOURNAL OF APPLIED POLYMER SCIENCE, 2007, 104 (03) :1475-1481

[10] Osmotic-driven release kinetics of bioactive therapeutic proteins from a biodegradable elastomer are linear, constant, similar, and adjustable [J].

Gu, F ;

Neufeld, R ;

Amsden, B .

PHARMACEUTICAL RESEARCH, 2006, 23 (04) :782-789

← 1 2 3 →