Structural biology of metal-binding sequences

被引：76
作者：
Opella, SJ
DeSilva, TM
Veglia, G
机构：
[1] Univ Calif San Diego, Dept Chem & Biochem, La Jolla, CA 92093 USA
[2] Childrens Hosp, Dept Neurol, Boston, MA 02115 USA
[3] Harvard Univ, Sch Med, Boston, MA 02115 USA
[4] Univ Minnesota, Dept Chem, Minneapolis, MN 55455 USA
来源：
CURRENT OPINION IN CHEMICAL BIOLOGY | 2002年 / 6卷 / 02期
关键词：
D O I：
10.1016/S1367-5931(02)00314-9
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
NMR spectroscopy and X-ray crystallography in conjunction with extended X-ray absorption fine structure spectroscopy, have contributed to the elucidation of the structural biology of protein-mediated mechanisms of heavy metal homeostasis. Among the most striking aspects of these investigations are the remarkable similarity of metal-ion-transport and sequestering systems across different species, and the need to continue the research to confirm hypotheses for the molecular mechanisms of transfers of metal ions between proteins.
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页码：217 / 223
页数：7
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