Autophagy and autophagy-related proteins in the immune system

被引：467

作者：

Shibutani, Shusaku T. ^{[1
,2
]}

Saitoh, Tatsuya ^{[3
]}

Nowag, Heike ^{[4
]}

Muenz, Christian ^{[4
]}

Yoshimori, Tamotsu ^{[1
,2
]}

机构：

[1] Osaka Univ, Grad Sch Frontier Biosci, Lab Intracellular Membrane Dynam, Osaka, Japan

[2] Osaka Univ, Grad Sch Med, Dept Genet, Osaka, Japan

[3] Univ Tokushima, Inst Enzyme Res, Div Mol Genet, Tokushima, Tokushima, Japan

[4] Univ Zurich, Inst Expt Immunol, Viral Immunobiol, CH-8091 Zurich, Switzerland

来源：

NATURE IMMUNOLOGY | 2015年 / 16卷 / 10期

基金：

瑞士国家科学基金会;

关键词：

MHC CLASS-II; GENOME-WIDE ASSOCIATION; T-CELL SURVIVAL; CHAIN; PROTEIN; CROSS-PRESENTATION; GENE ATG16L1; UNCONVENTIONAL SECRETION; INFLAMMASOME ACTIVATION; EPITHELIAL-CELLS; INNATE IMMUNITY;

D O I：

10.1038/ni.3273

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Autophagy is an intracellular bulk degradation system that is highly conserved in eukaryotes. The discovery of autophagy-related ('ATG') proteins in the 1990s greatly advanced the mechanistic understanding of autophagy and clarified the fact that autophagy serves important roles in various biological processes. In addition, studies have revealed other roles for the autophagic machinery beyond autophagy. In this Review, we introduce advances in the knowledge of the roles of autophagy and its components in immunity, including innate immunity, inflammatory responses and adaptive immunity.

引用

页码：1014 / 1024

页数：11

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