Anti-inflammatory and analgesic effects of Daphne retusa Hemsl

被引：26

作者：

Hu, Xiaojia ^{[1
]}

Jin, Huizi ^{[1
]}

Xu, Wenzheng ^{[1
]}

Zhang, Wei ^{[2
]}

Liu, Xiaohua ^{[2
]}

Yan, Shikai ^{[1
]}

Chen, Ming ^{[1
]}

Li, Jianqiang ^{[3
]}

Zhang, Wei-dong ^{[1
,2
]}

机构：

[1] Shanghai Jiao Tong Univ, Sch Pharm, Shanghai 200240, Peoples R China

[2] Second Mil Med Univ, Dept Phytochem, Shanghai 200433, Peoples R China

[3] Inst Forestry Sci, Ruanchuan 417500, Henan, Peoples R China

来源：

JOURNAL OF ETHNOPHARMACOLOGY | 2008年 / 120卷 / 01期

关键词：

Daphne retusa; Anti-inflammatory; Analgesic; Acute toxicity; NO; PGE(2);

D O I：

10.1016/j.jep.2008.07.010

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Daphne retusa Hemsl. belongs to the genus Daphne, a member of Thymelaeaceae family. The barks and stems of Daphne retusa are used as a folkloric medicine 'Zhu Shi Ma' in Western China because of its effects of detumescence and acesodyne. In this paper, we investigate the anti-inflammatory and analgesic effects of the 75% ethanol extract of the stems and barks of Daphne retusa and different fractions partitioned with petroleum ether, methylene chloride, ethyl acetate and n-butanol, respectively. The anti-inflammatory effects were evaluated using xylene-induced ear oedema in mice and carrageenan-induced paw oedema in rats, while the acetic acid-induced writhing test and hot-plate test as models for evaluating the centrally and peripherally analgesic activity. The results showed the plant has significant anti-inflammatory and analgesic effects (P < 0.05-0.01). Meanwhile, the result of the acute toxicity test at which the MTD was above 5 g/kg indicates that the plant extract is relatively safe in, and/or non-toxic to, mice. The findings of these experimental animal studies indicate that the Daphne retusa ethanol extract possesses anti-inflammatory and analgesic properties, and thus provide pharmacological support to folkloric, ethnomedical uses of 'Zhu shima' in the treatment and/of management of anti-inflammatory and painful conditions in China. Crown Copyright C 2008 Published by Elsevier Ireland Ltd. All rights reserved.

引用

页码：118 / 122

页数：5

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