Osteopontin Promoter Polymorphisms are Associated With Susceptibility to Gastric Cancer

被引：18

作者：

Lee, Teng-Yu ^{[3
]}

Lin, Jaw-Town ^{[5
]}

Wu, Cheng-Chung ^{[3
,6
]}

Yu, Cheng-Chan

Wu, Ming-Shiang ^{[7
]}

Lee, Tso-Ching ^{[2
]}

Chen, Hsiao-Ping ^{[4
]}

Wu, Chun-Ying ^{[1
,4
,6
]}

机构：

[1] China Med Univ, Dept Publ Hlth, Shenyang, Peoples R China

[2] Taichung Vet Gen Hosp, Mol Genet Lab, Taichung, Taiwan

[3] Chung Shan Med Univ, Dept Med, Taichung, Taiwan

[4] Natl Chung Hsing Univ, Dept Life Sci, Taichung 40227, Taiwan

[5] Fu Jen Catholic Univ, Sch Med, New Taipei City, Taiwan

[6] Natl Yang Ming Univ, Fac Med, Sch Med, Taipei 112, Taiwan

[7] Natl Taiwan Univ Hosp, Div Gastroenterol, Taipei, Taiwan

来源：

JOURNAL OF CLINICAL GASTROENTEROLOGY | 2013年 / 47卷 / 06期

关键词：

OPN; SNP; polymorphism; gastric cancer; HELICOBACTER-PYLORI INFECTION; TRANSCRIPTION FACTOR; GENE-EXPRESSION; UP-REGULATION; HEPATITIS-C; POPULATION; RISK; CARCINOGENESIS; METASTASIS; CARCINOMA;

D O I：

10.1097/MCG.0b013e31827b9325

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Goals: To evaluate the significance of osteopontin (OPN) genotypes in the susceptibility to gastric cancer. Background: The expression of OPN has been correlated with development, invasiveness, metastasis, and survival of gastric cancer, but the role of polymorphisms in the OPN promoter has not been investigated. Study: We enrolled 146 gastric cancer patients and 128 controls. DNA was extracted from peripheral blood leucocytes. Single-nucleotide polymorphisms (SNPs) in the OPN promoter (-66, -156, -443, -616, -1748, and -1776) were analyzed by pyrosequencing and direct sequencing methods. Logistic regression analyses were used to evaluate the associations between SNPs and development of gastric cancer. Results: SNP -443 C/C and -616 T/T of the OPN promoter were significantly associated with gastric cancer [odds ratio (OR)=2.88; 95% confidence interval (CI), 1.16-7.12 and OR=1.95; 95% CI, 1.35-2.82, respectively]. Analysis of the combined effect of OPN promoter SNPs revealed that the combination of SNP -443 (T/C or C/C) and SNP -616 (T/T or T/G) had the most significant association with gastric cancer (OR=3.95; 95% CI, 1.58-9.90). Conclusions: Our results suggest that polymorphisms in the OPN promoter are associated with the development of gastric cancer, and the combination of SNP -443 (T/C or C/C) and -616 (T/T or T/G) most significantly increases susceptibility to gastric cancer.

引用

页码：E55 / E59

页数：5

共 38 条

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