Risks of Reproducing with a Genetic Disorder

被引：9

作者：

Byler, Melissa Ciano ^{[1
]}

Lebel, Robert Roger ^{[1
]}

机构：

[1] SUNY Upstate Med Univ, Ctr Behav Dev & Genet, Syracuse, NY 13210 USA

来源：

SEMINARS IN REPRODUCTIVE MEDICINE | 2013年 / 31卷 / 04期

关键词：

male infertility; Klinefelter; XYY; AZF; androgen receptor; CFTR; ANDROGEN RECEPTOR GENE; INTRACYTOPLASMIC SPERM INJECTION; HUMAN Y-CHROMOSOME; LIGAND-BINDING DOMAIN; TRANSACTIVATION-REGULATING DOMAIN; CAG TRINUCLEOTIDE REPEATS; CYSTIC-FIBROSIS; KLINEFELTER-SYNDROME; SEX-CHROMOSOME; VAS-DEFERENS;

D O I：

10.1055/s-0033-1345273

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Male-factor infertility is the cause of reproductive issues in many couples. For approximately 15% of these men, the origin of the infertility is genetic. These causes include both chromosomal and single-gene disorders frequently impacting spermatogenesis. By identifying the genetic mechanism behind the infertility, we determine the ability of the couple to use assisted reproduction technologies. Use of these methods has ignited a new spectrum of concerns for the genetic competence of the offspring. By knowing what specific genetic risks exist for the offspring of men with these particular disorders, we are able to use preimplantation genetic diagnosis to detect these problems.

引用

页码：258 / 266

页数：9

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