Molecular Design of Synthetic Benzimidazoles for the Switchover of the Duplex to G-quadruplex DNA Recognition

被引：11

作者：

Maji, Basudeb ^{[1
]}

Bhattacharya, Santanu ^{[1
,2
,3
]}

机构：

[1] Indian Inst Sci, Dept Organ Chem, Bangalore 560012, Karnataka, India

[2] Jawaharlal Nehru Ctr Adv Sci Res, Chem Biol Unit, Bangalore 560012, Karnataka, India

[3] Dept Sci & Technol, New Delhi, India

来源：

CHIMIA | 2013年 / 67卷 / 1-2期

关键词：

Anti-cancer; Benzimidazole; Cytotoxicity; DNA; G-quadruplex; Telomerase; TRAP-LIG assay; MINOR-GROOVE; CRYSTAL-STRUCTURE; BINDING; STABILIZATION; MOTIF;

D O I：

10.2533/chimia.2013.39

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Benzimidazole derivatives are well known for their antibacterial, antiviral, anticonvulsant, antihistaminic, anthelmintic and antidepressant activities. Benzimidazole's unique base-selective DNA recognition property has been studied widely. However, most of the early benzimidazole systems have been targeted towards the binding of duplex DNA. Here we have shown the evolution and progress of the design and synthesis of new benzimidazole systems towards selective recognition of the double-stranded DNA first. Then in order to achieve selective recognition of the G-quadruplex DNA and utilize their potential as future anti-cancer drug candidates, we have demonstrated their selective cytotoxicity towards the cancer cells and potent telomerase inhibition ability.

引用

页码：39 / 43

页数：5

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