Ultraviolet light and melanoma

被引：40

作者：

Craig, Sarah ^{[1
]}

Earnshaw, Charles H. ^{[2
]}

Viros, Amaya ^{[1
]}

机构：

[1] Univ Manchester, CRUK Manchester Inst, Skin Canc & Ageing Lab, Manchester, Lancs, England

[2] Salford Royal NHS Fdn Trust, Dept Dermatol, Manchester, Lancs, England

来源：

JOURNAL OF PATHOLOGY | 2018年 / 244卷 / 05期

基金：

英国惠康基金;

关键词：

skin; epidermis; acute inflammation; TERT PROMOTER MUTATIONS; CYCLOBUTANE PYRIMIDINE DIMERS; MELANOCYTIC NEVI; SOLAR KERATOSES; BRAF MUTATIONS; DESMOPLASTIC MELANOMA; DIVERGENT PATHWAYS; DNA PHOTOPRODUCTS; HIGH-FREQUENCY; RISK-FACTORS;

D O I：

10.1002/path.5039

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Melanoma is a clinically heterogeneous disease, and current strategies for treatment of the primary tumour are based on pathological criteria alone. In the recent past, several DNA-sequencing and RNA-sequencing studies of primary and advanced melanoma samples have identified unique relationships between somatic mutations, genomic aberrations, and the genetic fingerprint of ultraviolet radiation (UVR). The recurrent patterns of genomic alterations reveal different disease pathways, drug targets and mechanisms limiting drug response. Here, we examine the known associations between the molecular categories of melanoma and the multidimensional UVR damage. Copyright (C) 2018 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.

引用

页码：578 / 585

页数：8

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