Ultraviolet light and melanoma

被引：39

作者：

Craig, Sarah ^{[1
]}

Earnshaw, Charles H. ^{[2
]}

Viros, Amaya ^{[1
]}

机构：

[1] Univ Manchester, CRUK Manchester Inst, Skin Canc & Ageing Lab, Manchester, Lancs, England

[2] Salford Royal NHS Fdn Trust, Dept Dermatol, Manchester, Lancs, England

来源：

JOURNAL OF PATHOLOGY | 2018年 / 244卷 / 05期

基金：

英国惠康基金;

关键词：

skin; epidermis; acute inflammation; TERT PROMOTER MUTATIONS; CYCLOBUTANE PYRIMIDINE DIMERS; MELANOCYTIC NEVI; SOLAR KERATOSES; BRAF MUTATIONS; DESMOPLASTIC MELANOMA; DIVERGENT PATHWAYS; DNA PHOTOPRODUCTS; HIGH-FREQUENCY; RISK-FACTORS;

D O I：

10.1002/path.5039

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Melanoma is a clinically heterogeneous disease, and current strategies for treatment of the primary tumour are based on pathological criteria alone. In the recent past, several DNA-sequencing and RNA-sequencing studies of primary and advanced melanoma samples have identified unique relationships between somatic mutations, genomic aberrations, and the genetic fingerprint of ultraviolet radiation (UVR). The recurrent patterns of genomic alterations reveal different disease pathways, drug targets and mechanisms limiting drug response. Here, we examine the known associations between the molecular categories of melanoma and the multidimensional UVR damage. Copyright (C) 2018 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.

引用

页码：578 / 585

页数：8

共 86 条

[1] The basal layer in human squamous tumors harbors more UVA than UVB fingerprint mutations: A role for UVA in human skin carcinogenesis [J].

Agar, NS ;

Halliday, GM ;

Barnetson, RS ;

Ananthaswamy, HN ;

Wheeler, M ;

Jones, AM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (14) :4954-4959

[2] Genomic Classification of Cutaneous Melanoma [J].

Akbani, Rehan ;

Akdemir, Kadir C. ;

Aksoy, B. Arman ;

Albert, Monique ;

Ally, Adrian ;

Amin, Samirkumar B. ;

Arachchi, Harindra ;

Arora, Arshi ;

Auman, J. Todd ;

Ayala, Brenda ;

Baboud, Julien ;

Balasundaram, Miruna ;

Balu, Saianand ;

Barnabas, Nandita ;

Bartlett, John ;

Bartlett, Pam ;

Bastian, Boris C. ;

Baylin, Stephen B. ;

Behera, Madhusmita ;

Belyaev, Dmitry ;

Benz, Christopher ;

Bernard, Brady ;

Beroukhim, Rameen ;

Bir, Natalie ;

Black, Aaron D. ;

Bodenheimer, Tom ;

Boice, Lori ;

Boland, Genevieve M. ;

Bono, Riccardo ;

Bootwalla, Moiz S. ;

Bosenberg, Marcus ;

Bowen, Jay ;

Bowlby, Reanne ;

Bristow, Christopher A. ;

Brockway-Lunardi, Laura ;

Brooks, Denise ;

Brzezinski, Jakub ;

Bshara, Wiam ;

Buda, Elizabeth ;

Burns, William R. ;

Butterfield, Yaron S. N. ;

Button, Michael ;

Calderone, Tiffany ;

Cappellini, Giancarlo Antonini ;

Carter, Candace ;

Carter, Scott L. ;

Cherney, Lynn ;

Cherniack, Andrew D. ;

Chevalier, Aaron ;

Chin, Lynda .

CELL, 2015, 161 (07) :1681-1696

[3] Signatures of mutational processes in human cancer [J].

Alexandrov, Ludmil B. ;

Nik-Zainal, Serena ;

Wedge, David C. ;

Aparicio, Samuel A. J. R. ;

Behjati, Sam ;

Biankin, Andrew V. ;

Bignell, Graham R. ;

Bolli, Niccolo ;

Borg, Ake ;

Borresen-Dale, Anne-Lise ;

Boyault, Sandrine ;

Burkhardt, Birgit ;

Butler, Adam P. ;

Caldas, Carlos ;

Davies, Helen R. ;

Desmedt, Christine ;

Eils, Roland ;

Eyfjord, Jorunn Erla ;

Foekens, John A. ;

Greaves, Mel ;

Hosoda, Fumie ;

Hutter, Barbara ;

Ilicic, Tomislav ;

Imbeaud, Sandrine ;

Imielinsk, Marcin ;

Jaeger, Natalie ;

Jones, David T. W. ;

Jones, David ;

Knappskog, Stian ;

Kool, Marcel ;

Lakhani, Sunil R. ;

Lopez-Otin, Carlos ;

Martin, Sancha ;

Munshi, Nikhil C. ;

Nakamura, Hiromi ;

Northcott, Paul A. ;

Pajic, Marina ;

Papaemmanuil, Elli ;

Paradiso, Angelo ;

Pearson, John V. ;

Puente, Xose S. ;

Raine, Keiran ;

Ramakrishna, Manasa ;

Richardson, Andrea L. ;

Richter, Julia ;

Rosenstiel, Philip ;

Schlesner, Matthias ;

Schumacher, Ton N. ;

Span, Paul N. ;

Teague, Jon W. .

NATURE, 2013, 500 (7463) :415-+

[4] Ultraviolet-radiation-induced inflammation promotes angiotropism and metastasis in melanoma [J].

Bald, Tobias ;

Quast, Thomas ;

Landsberg, Jennifer ;

Rogava, Meri ;

Glodde, Nicole ;

Lopez-Ramos, Dorys ;

Kohlmeyer, Judith ;

Riesenberg, Stefanie ;

van den Boorn-Konijnenberg, Debby ;

Hoemig-Hoelzel, Cornelia ;

Reuten, Raphael ;

Schadow, Benjamin ;

Weighardt, Heike ;

Wenzel, Daniela ;

Helfrich, Iris ;

Schadendorf, Dirk ;

Bloch, Wilhelm ;

Bianchi, Marco E. ;

Lugassy, Claire ;

Barnhill, Raymond L. ;

Koch, Manuel ;

Fleischmann, Bernd K. ;

Foerster, Irmgard ;

Kastenmueller, Wolfgang ;

Kolanus, Waldemar ;

Hoelzel, Michael ;

Gaffal, Evelyn ;

Tueting, Thomas .

NATURE, 2014, 507 (7490) :109-+

[5] The Molecular Pathology of Melanoma: An Integrated Taxonomy of Melanocytic Neoplasia [J].

Bastian, Boris C. .

ANNUAL REVIEW OF PATHOLOGY: MECHANISMS OF DISEASE, VOL 9, 2014, 9 :239-271

[6]

Bataille V, 1998, INT J CANCER, V78, P8, DOI 10.1002/(SICI)1097-0215(19980925)78:1<8::AID-IJC2>3.0.CO

[7]

2-U

[8] Risk factors of incident melanocytic nevi:: a longitudinal study in a cohort of 1,232 young German children [J].

Bauer, J ;

Büttner, P ;

Wiecker, TS ;

Luther, H ;

Garbe, C .

INTERNATIONAL JOURNAL OF CANCER, 2005, 115 (01) :121-126

[9] Melanoma genome sequencing reveals frequent PREX2 mutations [J].

Berger, Michael F. ;

Hodis, Eran ;

Heffernan, Timothy P. ;

Deribe, Yonathan Lissanu ;

Lawrence, Michael S. ;

Protopopov, Alexei ;

Ivanova, Elena ;

Watson, Ian R. ;

Nickerson, Elizabeth ;

Ghosh, Papia ;

Zhang, Hailei ;

Zeid, Rhamy ;

Ren, Xiaojia ;

Cibulskis, Kristian ;

Sivachenko, Andrey Y. ;

Wagle, Nikhil ;

Sucker, Antje ;

Sougnez, Carrie ;

Onofrio, Robert ;

Ambrogio, Lauren ;

Auclair, Daniel ;

Fennell, Timothy ;

Carter, Scott L. ;

Drier, Yotam ;

Stojanov, Petar ;

Singer, Meredith A. ;

Voet, Douglas ;

Jing, Rui ;

Saksena, Gordon ;

Barretina, Jordi ;

Ramos, Alex H. ;

Pugh, Trevor J. ;

Stransky, Nicolas ;

Parkin, Melissa ;

Winckler, Wendy ;

Mahan, Scott ;

Ardlie, Kristin ;

Baldwin, Jennifer ;

Wargo, Jennifer ;

Schadendorf, Dirk ;

Meyerson, Matthew ;

Gabriel, Stacey B. ;

Golub, Todd R. ;

Wagner, Stephan N. ;

Lander, Eric S. ;

Getz, Gad ;

Chin, Lynda ;

Garraway, Levi A. .

NATURE, 2012, 485 (7399) :502-506

[10] UV Signature Mutations [J].

Brash, Douglas E. .

PHOTOCHEMISTRY AND PHOTOBIOLOGY, 2015, 91 (01) :15-26

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