Rapid loss of response after withdrawal of treatment with azacitidine: a case series in patients with higher-risk myelodysplastic syndromes or chronic myelomonocytic leukemia

被引：36

作者：

Voso, Maria Teresa ^{[1
]}

Breccia, Massimo ^{[2
]}

Lunghi, Monia ^{[3
]}

Poloni, Antonella ^{[4
]}

Niscola, Pasquale ^{[5
]}

Finelli, Carlo ^{[6
]}

Bari, Alessia ^{[7
]}

Musto, Pellegrino ^{[8
]}

Zambello, Renato ^{[9
]}

Fianchi, Luana ^{[1
]}

Alimena, Giuliana ^{[2
]}

Leone, Giuseppe ^{[1
]}

机构：

[1] Univ Cattolica S Cuore, Dept Hematol, I-00198 Rome, Italy

[2] Univ Roma La Sapienza, Dept Hematol, Rome, Italy

[3] Univ Piemonte Orientale Amedeo Avogadro, Dept Hematol, Novara, Italy

[4] Univ Politecn Marche, Dept Hematol, Ancona, Italy

[5] Osped S Eugenio, Dept Hematol, Rome, Italy

[6] Univ Bologna, Dept Hematol, Bologna, Italy

[7] Univ Modena & Reggio Emilia, Dept Hematol, Modena, Italy

[8] Ctr Riferimento Oncol Basilicata, IRCCS, Unita Ematol & Trapianto Cellule Staminali, Rionero In Vulture, Italy

[9] Univ Padua, Dept Clin & Expt Med, Padua, Italy

来源：

EUROPEAN JOURNAL OF HAEMATOLOGY | 2013年 / 90卷 / 04期

关键词：

myelodysplastic syndromes; chronic myelomonocytic leukemia; hypomethylating agents; azacitidine; CONVENTIONAL CARE REGIMENS; SUPPORTIVE CARE; PHASE-III; DECITABINE; THERAPY; FAILURE;

D O I：

10.1111/ejh.12079

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

In patients with myelodysplastic syndromes (MDS), the likelihood of having a sustained response to azacitidine is increased by maximizing treatment duration. This is important as prognosis postrelapse is poor. There is also the concern that early termination of treatment may result in rapid disease progression. We reviewed outcomes in 13 patients who discontinued azacitidine (decitabine in one patient) while still responding to the treatment. Most patients rapidly relapsed; median time to progression was 5.4months. Reasons for treatment discontinuation included comorbidities, infections, and patient choice. These findings illustrate the risk of prematurely terminating azacitidine therapy in MDS.

引用

页码：345 / 348

页数：4

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