Homogeneous palladium-catalyzed asymmetric hydrogenation

被引：341

作者：

Chen, Qing-An ^{[1
]}

Ye, Zhi-Shi ^{[1
]}

Duan, Ying ^{[1
]}

Zhou, Yong-Gui ^{[1
]}

机构：

[1] Chinese Acad Sci, Dalian Inst Chem Phys, State Key Lab Catalysis, Dalian 116023, Peoples R China

来源：

CHEMICAL SOCIETY REVIEWS | 2013年 / 42卷 / 02期

基金：

中国国家自然科学基金;

关键词：

HIGHLY ENANTIOSELECTIVE SYNTHESIS; CONJUGATE REDUCTION; FACILE ACCESS; LIGANDS; COMPLEX; ACID; BOND;

D O I：

10.1039/c2cs35333d

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The transition metal catalyzed asymmetric hydrogenation of unsaturated compounds arguably presents one of the most attractive methods for the synthesis of chiral compounds. Over the last few decades, Pd has gradually grown up as a new and popular metal catalyst in homogeneous asymmetric hydrogenation the same as traditional Ru, Rh and Ir catalysts. Much progress has been successfully achieved in the asymmetric reduction of imines, enamines, olefins, ketones and heteroarenes. It was also found that palladium catalyzed asymmetric hydrogenation could be used as a key step in tandem reactions to quickly synthesize chiral compounds. This tutorial review intends to offer an overview of recent progress in homogeneous palladium catalyzed asymmetric hydrogenation and should serve as an inspiration for further advances in this area.

引用

页码：497 / 511

页数：15

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[1] Pd-catalyzed asymmetric hydrogenation of α-fluorinated iminoesters in fluorinated alcohol:: A new and catalytic enantioselective synthesis of fluoro α-amino acid derivatives [J].