'Non-genotoxic' carcinogens evaluated using the white-ivory assay of Drosophila melanogaster

被引：7
作者：
Consuegra, S [1 ]
Ferreiro, JA [1 ]
Sierra, LM [1 ]
Comendador, MA [1 ]
机构：
[1] UNIV OVIEDO,DEPT BIOL FUNC,AREA GENET,E-33071 OVIEDO,SPAIN
来源：
MUTATION RESEARCH-ENVIRONMENTAL MUTAGENESIS AND RELATED SUBJECTS | 1996年 / 359卷 / 02期
关键词：
non-genotoxic carcinogen; Ames-test negative carcinogen; Drosophila melanogaster; white-ivory assay; intrachromosomal recombination;
D O I：
10.1016/S0165-1161(96)90256-3
中图分类号：
X [环境科学、安全科学];
学科分类号：
08 ; 0830 ;
摘要：
Seven carcinogenic compounds (urethane, ethionine: auramine O, safrole, amitrole, acetamide and thioacetamide) were tested using the white-ivory (w(i)) assay of Drosophila melanogaster. These compounds were chosen because they were considered as Ames-test negative but produced positive results in the yeast DEL assay, which estimates the induction of intrachromosomal recombination. Only one compound, urethane, produced positive results in this w(i) assay, while the remaining were classified as negative. These results indicate that, in contrast with which has been postulated in yeast, these carcinogens do not induce any event associated to intrachromosomal recombination in D. melanogaster.
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收藏
页码：95 / 102
页数：8
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