Multimodality imaging of tumor integrin αvβ3 expression

被引：96
作者：
Chen, XY [1 ]
机构：
[1] Stanford Univ, Dept Radiol, Mol Imaging Program, MIPS, Stanford, CA 94305 USA
来源：
MINI-REVIEWS IN MEDICINAL CHEMISTRY | 2006年 / 6卷 / 02期
关键词：
tumor angiogenesis; molecular imaging; integrin alpha(v)beta(3); RGD peptide; positron emission tomography (PET);
D O I：
10.2174/138955706775475975
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Most solid tumors are angiogenesis dependent. Anti-angiogenic pharmaceuticals that inhibit the growth of new blood vessels offer considerable promise as anti-cancer agents. With increasing numbers of antiangiogenic drugs in clinical trials, there is an urgent need for detailed characterization of the heterogeneity of tumor vasculature and dissection of the complex network of mechanisms that control tumor angiogenesis. Non-invasive molecular imaging will play a key role in individualized anti-angiogenic therapy based upon molecular features of the new blood vessel growth. Integrin alpha(V)beta(3), which binds several ligands via an RGD tripeptide sequence, is uniquely expressed in tumor vasculature and aggressive tumor cells, making it a potential target for anti-angiogenic interventions. This review highlights some recent advances in multimodality imaging of tumor integrin expression with emphasis on positron emission tomography (PET).
引用
收藏
页码：227 / 234
页数：8
相关论文
共 51 条
[1]  
Abu-Hajir M, 2003, SEMIN THROMB HEMOST, V29, P309
[2]   The role of the microenvironment and intercellular cross-talk in tumor angiogenesis [J].
Ahmad, SA ;
Jung, YD ;
Liu, WB ;
Reinmuth, N ;
Parikh, A ;
Stoeltzing, O ;
Fan, F ;
Ellis, LM .
SEMINARS IN CANCER BIOLOGY, 2002, 12 (02) :105-112
[3]   Tumorigenesis and the angiogenic switch [J].
Bergers, G ;
Benjamin, LE .
NATURE REVIEWS CANCER, 2003, 3 (06) :401-410
[4]   REQUIREMENT OF VASCULAR INTEGRIN ALPHA(V)BETA(3) FOR ANGIOGENESIS [J].
BROOKS, PC ;
CLARK, RAF ;
CHERESH, DA .
SCIENCE, 1994, 264 (5158) :569-571
[5]   Tumor angiogenesis - new drugs on the block [J].
Brower, V .
NATURE BIOTECHNOLOGY, 1999, 17 (10) :963-968
[6]   Micro-PET Imaging of αvβ3-Integrin Expression with 18F-Labeled Dimeric RGD Peptide [J].
Chen, Xiaoyuan ;
Tohme, Michel ;
Park, Ryan ;
Hou, Yingping ;
Bading, James R. ;
Conti, Peter S. .
MOLECULAR IMAGING, 2004, 3 (02) :96-104
[7]   Integrin αVβ3-targeted imaging of lung cancer [J].
Chen, XY ;
Sievers, E ;
Hou, YP ;
Park, R ;
Tohme, M ;
Bart, R ;
Bremner, R ;
Bading, JR ;
Conti, PS .
NEOPLASIA, 2005, 7 (03) :271-279
[8]   In vivo near-infrared fluorescence imaging of integrin a,αvβ3 in brain tumor xenografts [J].
Chen, XY ;
Conti, PS ;
Moats, RA .
CANCER RESEARCH, 2004, 64 (21) :8009-8014
[9]  
Chen XY, 2004, J NUCL MED, V45, P1776
[10]   MicroPET imaging of brain tumor angiogenesis with 18F-labeled PEGylated RGD peptide [J].
Chen, XY ;
Park, R ;
Hou, YP ;
Khankaldyyan, V ;
Gonzales-Gomez, I ;
Tohme, M ;
Bading, JR ;
Laug, WE ;
Conti, PS .
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 2004, 31 (08) :1081-1089
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