Treatment Steps, Surgery, and Hospitalization Rates During the First Year of Follow-up in Patients with Inflammatory Bowel Diseases from the 2011 ECCO-Epicom Inception Cohort

被引：35

作者：

Vegh, Z. ^{[1
]}

Burisch, J. ^{[2
]}

Pedersen, N. ^{[3
]}

Kaimakliotis, I. ^{[4
]}

Duricova, D. ^{[5
]}

Bortlik, M. ^{[5
]}

Vinding, K. Kofod ^{[6
]}

Avnstrom, S. ^{[7
]}

Olsen, J. ^{[8
]}

Nielsen, K. R. ^{[8
]}

Katsanos, K. H. ^{[9
,10
]}

Tsianos, E. V. ^{[9
,10
]}

Lakatos, L. ^{[11
]}

Schwartz, D. ^{[12
,13
]}

Odes, S. ^{[12
,13
]}

D'Inca, R. ^{[14
,16
,17
,18
,19
,20
]}

Beltrami, M. ^{[15
,16
,17
,18
,19
,20
]}

Kiudelis, G. ^{[21
]}

Kupcinskas, L. ^{[21
]}

Jucov, A. ^{[22
]}

Turcan, S. ^{[22
]}

Barros, L. F. ^{[23
]}

Magro, F. ^{[24
,25
,26
]}

Lazar, D. ^{[27
]}

Goldis, A. ^{[27
]}

de Castro, L. ^{[28
]}

Hernandez, V. ^{[28
]}

Niewiadomski, O. ^{[29
]}

Bell, S. ^{[29
]}

Langholz, E. ^{[30
]}

Munkholm, P. ^{[31
]}

Lakatos, P. L. ^{[1
]}

机构：

[1] Semmelweis Univ, Dept Med 1, H-1083 Budapest, Hungary

[2] Hvidovre Univ Hosp, Med Sect, Gastrounit, DK-2650 Hvidovre, Denmark

[3] Slagelse Univ Hosp, Dept Gastroenterol, Slagelse, Denmark

[4] Nicosia Private Practice, Nicosia, Cyprus

[5] Charles Univ Prague, IBD Ctr ISCARE, Prague, Czech Republic

[6] Herlev Univ Hosp, Med Sect, Ctr Digest Dis, Copenhagen, Denmark

[7] Amager Hosp, Dept Med, Amager, Denmark

[8] Natl Hosp Faroe Isl, Dept Med, Torshavn, Faroe Islands, Denmark

[9] Univ Ioannina, Fac Med, Div Internal Med 1, GR-45110 Ioannina, Greece

[10] Univ Ioannina, Fac Med, Div Gastroenterol, GR-45110 Ioannina, Greece

[11] Csolnoky F Prov Hosp, Dept Med, Veszprem, Hungary

[12] Soroka Med Ctr, Dept Gastroenterol & Hepatol, IL-84101 Beer Sheva, Israel

[13] Ben Gurion Univ Negev, IL-84105 Beer Sheva, Israel

[14] Univ Padua, Azienda Osped, UO Gastroenterol, Padua, Italy

[15] Azienda Osped Arcispedale S Maria Nuova, Degenza Breve Internist & Ctr MICI, Reggio Emilia, Italy

[16] EpiCom Northern Italy Ctr Based Crema, Cremona, Italy

[17] EpiCom Northern Italy Ctr Based Crema, Florence, Italy

[18] EpiCom Northern Italy Ctr Based Crema, Forli, Italy

[19] EpiCom Northern Italy Ctr Based Crema, Padua, Italy

[20] EpiCom Northern Italy Ctr Based Crema, Reggio Emilia, Italy

[21] Lithuanian Univ Hlth Sci, Inst Digest Res, Kaunas, Lithuania

[22] State Univ Med & Pharm, Dept Gastroenterol, Kishinev, Moldova

[23] Hosp Vale Sousa, Oporto, Portugal

[24] Hosp Sao Joao, Dept Gastroenterol, Oporto, Portugal

[25] Oporto Med Sch, Dept Pharmacol & Therapeut, Oporto, Portugal

[26] Univ Porto, MedInUP Ctr Drug Discovery & Innovat Med, P-4100 Oporto, Portugal

[27] Univ Med Victor Babes, Gastroenterol Clin, Timisoara, Romania

[28] SERGAS, Xerencia Xest Integrada Vigo, Inst Invest Biomed IBI, Dept Gastroenterol,Grp Invest Patol Digest, Vigo, Spain

[29] St Vincents Hosp, Dept Gastroenterol, Melbourne, Vic, Australia

[30] Herlev & Gentofte Hosp, Dept C, Gastroenterol Sect, Hellerup, Denmark

[31] Univ Copenhagen, North Zealand Hosp, Med Sect, Gastro Unit, DK-1168 Copenhagen, Denmark

来源：

JOURNAL OF CROHNS & COLITIS | 2015年 / 9卷 / 09期

关键词：

Inflammatory bowel diseases; surgery; hospitalization; CROHNS-DISEASE; WESTERN HUNGARY; CLINICAL-COURSE; EUROPE; COLITIS;

D O I：

10.1093/ecco-jcc/jjv099

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

The ECCO-EpiCom study investigates the differences in the incidence and therapeutic management of inflammatory bowel diseases [IBD] between Eastern and Western Europe. The aim of this study was to analyse the differences in the disease phenotype, medical therapy, surgery, and hospitalization rates in the ECCO-EpiCom 2011 inception cohort during the first year after diagnosis. Nine Western, five Eastern European centres and one Australian centre with 258 Crohn's disease [CD], 380 ulcerative colitis [UC] and 71 IBD unclassified [IBDU] patients [female/male: 326/383; mean age at diagnosis: 40.9 years, SD: 17.3 years] participated. Patients' data were registered and entered in the web-based ECCO-EpiCom database [www.epicom-ecco.eu]. In CD, 36 [19%] Western Europe/Australian and 6 [9%] Eastern European patients received biological therapy [p = 0.04], but the immunosuppressive [IS] use was equal and high in these regions [Eastern Europe vs Western Europe/Australia: 53% vs 45%; p = 0.27]. Surgery was performed in 17 [24%] CD patients in Eastern Europe and 13 [7%] in Western Europe/Australia [p < 0.001, pLogRank = 0.001]. Of CD patients from Eastern Europe, 24 [34%] were hospitalized, and 39 [21%] from Western Europe/Australia, [p = 0.02, pLogRank = 0.01]. In UC, exposure to biologicals and colectomy rates were low and hospitalization rates did not differ between these regions during the 1-year follow-up period [16% vs 16%; p = 0.93]. During the first year after diagnosis, surgery and hospitalization rates were significantly higher in CD patients in Eastern Europe compared with Western Europe/Australia, whereas significantly more CD patients were treated with biologicals in the Western Europe/Australian centres.

引用

页码：747 / 753

页数：7

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