Possibility of detecting intraductal papillary mucinous neoplasms using metabolite biomarkers for pancreatic cancer

被引：1

作者：

Nakano, Ryota ^{[1
]}

Nishiumi, Shin ^{[1
,2
]}

Kobayashi, Takashi ^{[1
]}

Ikegawa, Takuya ^{[1
]}

Kodama, Yuzo ^{[1
]}

Yoshida, Masaru ^{[1
,3
,4
]}

机构：

[1] Kobe Univ, Grad Sch Med, Dept Internal Med, Div Gastroenterol, Kobe, Hyogo, Japan

[2] Hyogo Coll Med, Dept Om Med, Nishinomiya, Hyogo, Japan

[3] Kobe Univ, Grad Sch Med, Dept Internal Related, Div Metabol Res, Kobe, Hyogo, Japan

[4] AMED, AMED CREST, Kobe, Hyogo, Japan

来源：

BIOMARKERS IN MEDICINE | 2020年 / 14卷 / 11期

基金：

日本学术振兴会;

关键词：

biomarker; gas chromatography; mass spectrometry; intraductal papillary mucinous neoplasms; metabolite; metabolomics; pancreatic cancer; pancreatic cyst; risk factor; screening; INTERNATIONAL-CONSENSUS-GUIDELINES; BODY-MASS INDEX; SERUM METABOLOMICS; DIAGNOSTIC-APPROACH; DIABETES-MELLITUS; RISK; MANAGEMENT; IPMN; SURVEILLANCE; METAANALYSIS;

D O I：

10.2217/bmm-2019-0587

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Aim:The aim of this study was to identify whether metabolite biomarker candidates for pancreatic cancer (PC) could aid detection of intraductal papillary mucinous neoplasms (IPMN), recognized as high-risk factors for PC.Materials & methods:The 12 metabolite biomarker candidates, which were found to be useful to detect PC in our previous study, were evaluated for plasma samples from patients with PC (n = 44) or IPMN (n = 24) or healthy volunteers (n = 46).Results:Regarding the performance of individual biomarkers of PC and PC high-risk IPMN, lysine exhibited the best performance (sensitivity: 67.8%; specificity: 86.9%). The multiple logistic regression analysis-based detection model displayed high sensitivity and specificity values of 92.5 and 90.6%, respectively.Conclusion:Metabolite biomarker candidates for PC are useful for detecting high-risk IPMN, which can progress to PC.

引用

页码：1009 / 1020

页数：12

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